温度感受性に基づく代謝機能回復因子の網羅的探索と新規治療法の開発

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To clarify the molecular mechanism of a temperature-sensitive(TS) phenotype in peroxisomal biogenesis disorders(PBD), we analyzed the change of gene expression in the fibroblasts from PBD patients at 37℃and 30℃, using micro array method. Several hypoxia inducible genes may be possible to associate with TS phenomenon, therefore, we continue further study at a condition of hypoxia. Furthermore, we demonstrated mice fed on high-fat diet(HFD) induced hepatic gene expression of peroxisomal metabolism, which may provide useful fundamental information to understand the role of the peroxisomal function in obesity and lifestyle-related diseases.