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Predisposition of cancer development by global analysis of DNA methylation alterations

Predisposition of cancer development by global analysis of DNA methylation alterations
通过 DNA 甲基化改变的整体分析来了解癌症发展的倾向
批准号:
21591710
负责人:
SUZUKI Koichi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
We evaluated the levels of demethylation alterations in normal tissues from patients who had undergone gastrectomy or colectomy due to cancer development. Our data showed that high levels of demethylation alterations were frequently seen in patients who developed synchronous or metachronous double cancers as compare with those did not. Further, we developed a novel microarray platform based on methylation-sensitive amplified fragment length polymorphism DNA fingerprinting to perform the genome-wide severance of methylation alterations, which would enable us to make biological profiles according to the several diseases including cancer.
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DOI: 10.1038/onc.2011.652
发表时间: 2012-11-29
期刊: ONCOGENE
影响因子: 8
作者: [Kamiyama, H., Suzuki, K., Maeda, T., Koizumi, K., Miyaki, Y., Okada, S., Kawamura, Y. J., Samuelsson, J. K., Alonso, S., Konishi, F., Perucho, M.]
通讯作者: Perucho, M.
多発大腸癌非癌部大腸粘膜の遺伝子変化から大腸癌異時発生の危険性を予測する
从多种结直肠癌的非癌性结直肠粘膜的基因变化预测结直肠癌异时发展的风险
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [神山英範, 鈴木浩一, 前田孝文, 小泉圭, 宮木祐一郎, 河村裕, 小西文雄]
通讯作者: 小西文雄
大腸癌細胞株におけるDNA脱メチル化異常と染色体不安定性
结直肠癌细胞系中 DNA 去甲基化异常和染色体不稳定
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [前田孝文, 鈴木浩一, 早田邦康, 河村裕, 辻仲眞康, 加納良彦, 神山英憲, 小西文雄]
通讯作者: 小西文雄
Sessile serrated adenoma of the colon as a precursor of colon Cancer
结肠无蒂锯齿状腺瘤是结肠癌的前兆
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Konishi F, Maeda T, Suzuki K, Togashi K]
通讯作者: Togashi K
32
    Identification of molecules involved in genomic damage and their blood monitoring
    • 批准号:
      16K10514
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2016
    • 负责人:
      SUZUKI Koichi
    • 依托单位:
    Effects of innate immune activation induced by infection or tissue damage on the development of thyroid autoimmunity
    • 批准号:
      24591375
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.49万
    • 财政年份:
      2012
    • 负责人:
      SUZUKI Koichi
    • 依托单位:
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    • 批准号:
      23560246
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2011
    • 负责人:
      SUZUKI Koichi
    • 依托单位:
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    • 批准号:
      21591187
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2009
    • 负责人:
      SUZUKI Koichi
    • 依托单位:
    海外基金