Predisposition of cancer development by global analysis of DNA methylation alterations
Predisposition of cancer development by global analysis of DNA methylation alterations
批准号:
21591710
负责人:
SUZUKI Koichi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We evaluated the levels of demethylation alterations in normal tissues from patients who had undergone gastrectomy or colectomy due to cancer development. Our data showed that high levels of demethylation alterations were frequently seen in patients who developed synchronous or metachronous double cancers as compare with those did not. Further, we developed a novel microarray platform based on methylation-sensitive amplified fragment length polymorphism DNA fingerprinting to perform the genome-wide severance of methylation alterations, which would enable us to make biological profiles according to the several diseases including cancer.
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DOI:
10.1038/onc.2011.652
发表时间:
2012-11-29
期刊:
ONCOGENE
影响因子:
8
作者:
[Kamiyama, H., Suzuki, K., Maeda, T., Koizumi, K., Miyaki, Y., Okada, S., Kawamura, Y. J., Samuelsson, J. K., Alonso, S., Konishi, F., Perucho, M.]
通讯作者:
Perucho, M.
多発大腸癌非癌部大腸粘膜の遺伝子変化から大腸癌異時発生の危険性を予測する
从多种结直肠癌的非癌性结直肠粘膜的基因变化预测结直肠癌异时发展的风险
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[神山英範, 鈴木浩一, 前田孝文, 小泉圭, 宮木祐一郎, 河村裕, 小西文雄]
通讯作者:
小西文雄
大腸癌細胞株におけるDNA脱メチル化異常と染色体不安定性
结直肠癌细胞系中 DNA 去甲基化异常和染色体不稳定
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[前田孝文, 鈴木浩一, 早田邦康, 河村裕, 辻仲眞康, 加納良彦, 神山英憲, 小西文雄]
通讯作者:
小西文雄
Sessile serrated adenoma of the colon as a precursor of colon Cancer
结肠无蒂锯齿状腺瘤是结肠癌的前兆
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Konishi F, Maeda T, Suzuki K, Togashi K]
通讯作者:
Togashi K
右側結腸癌の組織発生におけるsessile serrated adenoma/polyp(SSA/SSP)の役割-遺伝子変化の病理組織所見による分析-
无蒂锯齿状腺瘤/息肉(SSA/SSP)在右侧结肠癌组织发生中的作用 - 根据组织病理学结果分析遗传变化 -
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[小西文雄, 前田孝文, 鈴木浩一, 野田弘志]
通讯作者:
野田弘志
共 32 条
Identification of molecules involved in genomic damage and their blood monitoring
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批准号:16K10514
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2016
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负责人:SUZUKI Koichi
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依托单位:
Effects of innate immune activation induced by infection or tissue damage on the development of thyroid autoimmunity
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批准号:24591375
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2012
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依托单位:
On mechanism of microbubble emission boiling and the application for high heat flux cooling technology
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批准号:23560246
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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Innate immune activation and thyroid autoimmunity
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批准号:21591187
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2009
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负责人:SUZUKI Koichi
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依托单位:
DNA methylation alterations and their relationship to genomic instability in gastrointestinal cancer
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批准号:17591387
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2005
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负责人:SUZUKI Koichi
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依托单位:
Changes in gene expression profile and development of autoimmunity in the thyroid following infection.
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批准号:15390296
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.0万
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财政年份:2003
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负责人:SUZUKI Koichi
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依托单位:
AN INVESTIGATION OF MICROBUBBLE EMISSION BOILING AND APPLICATION TO ULTRA-HIGH HEAT FLUX COOLING TECHNOLOGY FOR HIGH POWERED ELECTRONIC DEVICES
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批准号:14550200
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2002
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负责人:SUZUKI Koichi
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依托单位:
Developmental use of novel-bioactive agents identified from Bombyx mori and wild silkmoths
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批准号:12356002
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$27.17万
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财政年份:2000
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负责人:SUZUKI Koichi
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依托单位:
Analysis of Activation Mechanism of Calpain on the Basis of its Tertiary Structure
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批准号:12308032
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$21.7万
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财政年份:2000
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负责人:SUZUKI Koichi
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Mutation detection of cardiac ion channel genes in sudden death cases
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批准号:11470121
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.32万
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财政年份:1999
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负责人:SUZUKI Koichi
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依托单位:
STUDY ON ANALYTICAL MODEL OF RUNOFF-EROSION DUE TO RAINFALL IN BRAZILIAN SEMI-ARID REGION
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批准号:11695052
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.58万
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负责人:SUZUKI Koichi
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依托单位:
Bed form and bed load variation of each grain size due to discharge change in mountain rivers with sand gravel mixture
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批准号:09650568
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资助金额:$1.86万
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Genetic recombination in the ABO blood group gene region
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批准号:09670456
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资助金额:$1.92万
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财政年份:1997
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负责人:SUZUKI Koichi
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依托单位:
Analysis of molecular mechanism of muscular dystrophy involving skeletal muscle-specific calpain and connectin
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批准号:09044208
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$3.33万
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财政年份:1997
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负责人:SUZUKI Koichi
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依托单位:
Development of Artificial haching in the wild silkmoth, Antheraea yamamai
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批准号:08556010
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$10.69万
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财政年份:1996
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负责人:SUZUKI Koichi
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依托单位:
Structure and Function of New Neurotransmitters in Brains in the Silkworm Bombyx Mori
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批准号:08406005
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$12.1万
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财政年份:1996
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负责人:SUZUKI Koichi
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依托单位:
Mechanism of Selective Degradation of Proteins
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批准号:08278102
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$214.14万
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财政年份:1996
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负责人:SUZUKI Koichi
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依托单位:
Hot spot for genetic recombination in the coagulation factor XIII a subunit gene
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批准号:07670508
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1995
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负责人:SUZUKI Koichi
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依托单位:
Determination and regulation of half-life of the proteins
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批准号:07558094
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$9.6万
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Structure and function of hormones controlling diapause of pharate first-instar larvae in the wild silkmoth, Antheraea yamamai.
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批准号:05454063
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资助金额:$4.35万
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负责人:SUZUKI Koichi
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依托单位:
海外基金