Cancer specific delivery of magnetic nanoparticles.

磁感应加热癌症治疗的临床应用中，磁性纳米颗粒对癌组织的特异性积累是必不可少的基础技术。传统的方法，即肿瘤特异性抗体偶联纳米颗粒，只赋予0.2mg/g肿瘤积累。为了使更多的颗粒沉淀到肿瘤中，我们尝试创新了生物化和航空化磁性纳米颗粒交替施用的多步骤给药方法。然而，由于肝脏中Kpper细胞的非特异性捕获，这种方法无法将纳米颗粒积聚到肿瘤中。当我们尝试另一种方法，即用原始独特的PEG修饰非颗粒表面时，肿瘤蓄积达到0.58mg/g。

For clinical application of induction heating cancer therapy, specific accumulation of magnetic nanoparticles to cancer tissue is a indispensable fundamental technique. Conventional approach, viz. tumor specific antibody conjugate nanoparticle, confer only 0.2mg/g tumor accumulation. Intending to precipitate more particles to tumor, we have tried to innovate multiple step administration of biotinaized and avidinaized magnetic nanoparticles alternateively. This approach, however, failed to accumulate nanoparticles to tumor, due to non-specific trap by Kpper cells in liver. When we tried alternative approach, i.e. decoration of nonparticle surface with original unique PEG, 0.58mg/g tumor accumulation have achieved.