Cancer specific delivery of magnetic nanoparticles.

对于感应加热治疗癌症的临床应用来说，磁性纳米粒子在肿瘤组织中的特异性积聚是一项不可或缺的基础技术。传统方法，即。肿瘤特异性抗体偶联纳米粒，仅有0.2 mg/g的肿瘤蓄积。为了将更多的颗粒沉淀到肿瘤中，我们尝试了生物素化和胺化磁性纳米粒交替多步给药的方法。然而，由于Kpper细胞在肝脏中的非特异性捕获，这种方法未能将纳米颗粒积聚到肿瘤上。当我们尝试另一种方法，即用原始唯一的聚乙二醇修饰非颗粒表面时，肿瘤聚集量达到了0.58 mg/g。

For clinical application of induction heating cancer therapy, specific accumulation of magnetic nanoparticles to cancer tissue is a indispensable fundamental technique. Conventional approach, viz. tumor specific antibody conjugate nanoparticle, confer only 0.2mg/g tumor accumulation. Intending to precipitate more particles to tumor, we have tried to innovate multiple step administration of biotinaized and avidinaized magnetic nanoparticles alternateively. This approach, however, failed to accumulate nanoparticles to tumor, due to non-specific trap by Kpper cells in liver. When we tried alternative approach, i.e. decoration of nonparticle surface with original unique PEG, 0.58mg/g tumor accumulation have achieved.