Evaluation of the signal transduction that controls hepatic sinusoidal regeneration and attempt to promote liver regeneration using endothelial progenitor cells.

评估控制肝窦再生的信号转导，并尝试使用内皮祖细胞促进肝再生。

• 批准号: 21591744
• 负责人: SHIMIZU Hiroaki
• 金额: $ 2.91万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591744/
• 关键词: 肝再生; 類洞内皮細胞; 血管内皮前駆細胞; 肝切除

VEGF secreted by hepatocytes may play a key role in SEC proliferation, followed by increased Ang-1, presumably promoting sinusoidal maturation. Thereafter, Ang-2 mainly released from HSCs in the absence of VEGF may contribute to apoptosis of superfluous SECs for cessation of the regenerative process. In conclusion, Ang-Tie system, together with VEGF plays a critical role in regulating balance between SEC proliferation and apoptosis during sinusoidal regeneration after hepatectomy

肝细胞分泌的VEGF可能在SEC增殖中起关键作用，其次是Ang-1的增加，可能促进了窦状动脉的成熟。因此，在缺乏VEGF的情况下，主要从hsc中释放的Ang-2可能会导致多余的SECs凋亡，从而停止再生过程。综上所述，Ang-Tie系统与VEGF在肝切除术后肝窦再生过程中调控SEC增殖与凋亡的平衡中起关键作用

项目成果

Intrahepatic cholangiojejunostomy (Longmire procedure) for recurrent bilioenteric anastomotic stricture with hepatolithiasis.

肝内胆管空肠吻合术（Longmire 手术）治疗复发性胆肠吻合口狭窄伴肝石症。

• 发表时间: 2011
• 期刊: Hepato-Gastroenterology
• 作者: Shimizu H;et al
• 通讯作者: et al

Effect of excessive acute-phase response on liver regeneration after partial hepatectomy in rats.

过度急性时相反应对大鼠部分肝切除术后肝再生的影响。

• 发表时间: 2009
• 期刊: Hepatogastroenterology 56
• 作者: Kusashio K;Shimizu H;Kimura F;Yoshidome H;Ohtsuka M;Kato A;Yoshitomi H;Furukawa K;Fukada T;Miyazaki M.
• 通讯作者: Miyazaki M.

Induction of Antitumor Response by in Vivo Allogeneic Major Histocompatibility Complex Gene Transfer Using Electroporation

使用电穿孔体内同种异体主要组织相容性复合体基因转移诱导抗肿瘤反应

• 发表时间: 2009
• 期刊: J Surg Res (in press)
• 作者: Shimizu H;Nukui Y;Kimura F;Yoshidome H;Ohtsuka M;Kato A;Miyazaki M
• 通讯作者: Miyazaki M

Aggressive Surgical Resection for Hilar Cholangiocarcinoma of the Left-Side Predominance Radicality and Safety of Left-Sided Hepatectomy

• DOI: 10.1097/sla.0b013e3181be0085
• 发表时间: 2010-02-01
• 期刊: ANNALS OF SURGERY
• 影响因子: 9
• 作者: Shimizu, Hiroaki;Kimura, Fumio;Miyazaki, Masaru
• 通讯作者: Miyazaki, Masaru

Intrahepatic cholangiojejunostomy (Longmire procedure) for recurrent bilioeteric nanastomotic stricture with hepatolithiasis

肝内胆管空肠吻合术（Longmire 手术）治疗复发性胆管吻合口狭窄伴肝管结石

• 发表时间: 2012
• 期刊: Hepato-Gastroenterology
• 作者: Shimizu H;et al.
• 通讯作者: et al.