Neuroprotective effects of PPARγon ischemic neuronal injury

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Synthetic peroxisome proliferator-activated receptorγ(PPARγ) ligands, thiazolidinediones, are used for the treatment of type 2diabetes. In addition, they have pleiotropic effects such as neuroprotective effects against ischemic neuronal injury ; however, the mechanism of neuroprotective effects is still obscure. In this study, we examined the expression of PPARγafter transient forebrain ischemia, and assessed the neuroprotective effects of thiazolidinediones in this model. We also studied the effects of thiazolidinediones on Akt/GSK-3βand STAT3, key pathways of prosurvival signaling after ischemia. We revealed that PPARγis upregulated mainly in neurons after ischemia, and thiazolidinediones have a neuroprotective effects against ischemic neuronal injury via activation of Akt/GSK-3βand STAT3pathways.