Detection of brain ischemia in patients with traumatic brain injury using molecular imaging positron emission tomography

使用^<18 b> f -氟米唑（FMISO）正电子发射断层扫描（PET）对外伤性脑损伤患者的周围脑挫伤未发现缺氧区。然后，我们尝试在缺血性脑卒中和恶性脑肿瘤患者中检测缺氧区。所有急性脑梗死患者均表现为脑梗死周围缺氧区，部分缺氧区导致亚急性期脑梗死。在恶性胶质瘤患者中，所有肿瘤均表现为肿瘤组织缺氧，缺氧量与蛋氨酸PET测定的生物侵袭性体积显著相关。

No hypoxic area was detected in surrounding brain contusion using^<18> F-fluoromisonidazole(FMISO) positron emission tomography(PET) in patients with traumatic brain injury. Then, we tried to detect hypoxic area in patients with ischemic stroke and malignant brain tumor. All patients with acute cerebral infarction showed hypoxic area surrounding cerebral infarction and some of the hypoxic area resulted in cerebral infarction in the subacute phase. In patients with malignant gliomas, all tumors showed tissue hypoxia in the tumor and the hypoxia volume was significantly correlated with the volume of biological aggressiveness determined by methionine PET.