Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats

近年来的研究表明，合成抗氧化剂没食子酸丙酯(PG)在常氧条件下能激活培养细胞中的缺氧诱导因子-1(HIF-1)。本研究旨在验证给予PG可减轻大鼠前脑缺血模型神经元损伤的假说。结果表明，在中度(8min)而不是重度(10min)的大鼠前脑缺血模型中，腹腔注射半乳糖酸正丙酯可能具有神经保护作用。

Recent evidence indicated that n-propyl gallate (PG), a synthetic antioxidant, activates hypoxia-inducible factor 1 (HIF-1) under normoxic conditions in cultured cells. The present study was conducted to test the hypothesis that the administration of PG may attenuate neuronal injury in a rat model of forebrain ischemia. The results indicated that intraperitoneal administration of n-propyl galate may have neuroprotective effects in a model of moderate(8min), but not severe(10min), forebrain ischemia in rats.