Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats
Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats
批准号:
21591984
负责人:
KAWANO Yasunobu
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012
中文摘要
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英文摘要
Recent evidence indicated that n-propyl gallate (PG), a synthetic antioxidant, activates hypoxia-inducible factor 1 (HIF-1) under normoxic conditions in cultured cells. The present study was conducted to test the hypothesis that the administration of PG may attenuate neuronal injury in a rat model of forebrain ischemia. The results indicated that intraperitoneal administration of n-propyl galate may have neuroprotective effects in a model of moderate(8min), but not severe(10min), forebrain ischemia in rats.
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会议论文
Effect of n-Propyl Gallate on neuronal survival after forebrain ischemia in rats
没食子酸正丙酯对大鼠前脑缺血后神经元存活的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kawano Y, Kawaguchi M, Hirota K, Kai S, Konishi N, Furuya H, Kawano Yasunobu, 川口昌彦]
通讯作者:
川口昌彦
DOI:
10.1016/j.resuscitation.2011.07.024
发表时间:
2012-02-01
期刊:
RESUSCITATION
影响因子:
6.5
作者:
[Kawano, Yasunobu, Kawaguchi, Masahiko, Furuya, Hitoshi]
通讯作者:
Furuya, Hitoshi
海外基金