Vestibular functions at the Meniere's attack and after treatment

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We produced a new animal model for Meniere’s disease. This model consists of hypo-function of endolymphatic sac and administration of vasopressin. This model showed larger endolymphatic hydrops than those of hypo-function of endolymphatic sac only and administration of vasopressin only. Moreover, this model showed spontaneous nystagmus and balance disorder. These results indicate that hypo-function of endolymphatic sac in combination with high plasma level of vasopressin would induce vertiginous attack of Meniere’s disease. Further, we administered V2R antagonist to the new animal model for Meniere’s disease. The animal showed decrease in endolymphatic hydrops and did not show spontaneous nystagmus or balance disorder. This result implies that V2R antagonist might be used for a treatment of Meniere’s disease.