Effect of Artificial Endolymph Injection into the Cochlear Duct on Perilymph Potassium

耳蜗管人工内淋巴注射对外淋巴钾的影响

基本信息

  • 批准号:
    16591714
  • 负责人:
  • 金额:
    $ 2.18万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2004
  • 资助国家:
    日本
  • 起止时间:
    2004 至 2005
  • 项目状态:
    已结题

项目摘要

The pathological feature of Meniere's disease is endolymphatic hydrops. However, the causes of symptoms during Meniere's attacks remain unclear. One hypothesis of the Meniere's attack is that endolymphatic hydrops causes perilymphatic potassium increase and the potassium has a toxic effect on the eighth nerve.^<1,2> The results from temporal bone histopathology of Meniere's disease that include the rupture of the Reissner's membrane support this hypothesis. If it is the case, high K^+ of endolymph should leak into scala vestibuli. The higher K^+ in scala vestibuli could propagate into scala tympani through the spiral ligament and, in apical regions, through the helicotrema. However, the cause of K^+ leakage from endolymph could occur not only from a rupture of the Reissner's membrane but also from a permeability change of the cochlear duct without rupture, suggested by observations that Reissner's membrane ruptures are not observed in all temporal bones following attacks. The purpose of this study is to investigate the relationship between endolymphatic hydrops and perilymphatic potassium under conditions without Reissner's membrane rupture.
梅尼埃病的病理特征是内淋巴积液。然而,梅尼埃发作期间症状的原因尚不清楚。关于梅尼埃氏病的一种假设是,内淋巴积液导致淋巴周围钾增加,钾对第八神经有毒性作用。^<1,2 bb0梅尼埃氏病的颞骨组织病理学结果,包括雷氏膜破裂,支持这一假设。如果是这样,高K^+的内淋巴应渗漏到前庭阶梯。前庭鳞片中较高的K^+可通过螺旋韧带向中鼓鳞片传播,在根尖区可通过螺旋孔向中鼓鳞片传播。然而,内淋巴K^+渗漏的原因不仅可能是赖斯纳膜破裂,也可能是耳蜗导管渗透性改变而没有破裂,观察表明,并不是所有颞骨在攻击后都观察到赖斯纳膜破裂。本研究的目的是探讨在没有赖氏膜破裂的情况下,淋巴内积液和淋巴外钾的关系。

项目成果

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KAKIGI Akinobu其他文献

KAKIGI Akinobu的其他文献

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{{ truncateString('KAKIGI Akinobu', 18)}}的其他基金

Vestibular functions at the Meniere's attack and after treatment
梅尼埃发作时和治疗后的前庭功能
  • 批准号:
    21592159
  • 财政年份:
    2009
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Studies of a possible mechanism underlying the attack of Meniere's disease and its treatment
梅尼埃病发病机制及其治疗的研究
  • 批准号:
    19591977
  • 财政年份:
    2007
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The effects of hormones on trafficking in the endolymphatic sac
激素对内淋巴囊运输的影响
  • 批准号:
    14571622
  • 财政年份:
    2002
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
HORMONAL REGULATION OF INNER EAR FLUID IN THE INTERMEDIATE CELLS OF THE STRIA VASCULARIS
血管纹中间细胞内耳液的激素调节
  • 批准号:
    09671750
  • 财政年份:
    1997
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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