Immune regulation of oral disease by co-signal molecule B7-H3 and the novel receptor.

共信号分子 B7-H3 和新型受体对口腔疾病的免疫调节。

• 批准号: 21592385
• 负责人: HASHIGUCHI Masaaki
• 金额: $ 2.83万
• 依托单位: Dokkyo Medical University (2010-2011)Tokyo Medical and Dental University (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592385/
• 关键词: 免疫; 感染; 炎症; ヒト免疫応答; 補助シグナル; B7-H3; TLT2; 抗腫瘍免疫; Tlt2

Co-signal molecules play important roles in positively or negatively regulate cell responses. We previously reported that new cosignal ligand murine B7-H3 and the receptor TLT-2 enhance T cell responses. Here we investigate the precise mechanisms and found, in human system, B7-H3 upregulate T cell responses through the ligation with TLT-2, too. We also clarified TLT-2 upregulates anti-tumor immunity through the enhancement of cytotoxicity by CD8^+T cells. These suggest that B7-H3.TLT-2 enhances anti-tumor immunity and imply that strong or continuous B7-H3.TLT-2 signaling lowers TLT-2.

共信号分子在正向或负向调节细胞反应中发挥重要作用。我们之前报道过新的共信号配体鼠 B7-H3 和受体 TLT-2 增强了 T 细胞反应。在这里，我们研究了精确的机制，发现在人体系统中，B7-H3 也通过与 TLT-2 连接来上调 T 细胞反应。我们还阐明了 TLT-2 通过增强 CD8^+T 细胞的细胞毒性来上调抗肿瘤免疫。这些表明 B7-H3.TLT-2 增强抗肿瘤免疫力，并意味着强烈或连续的 B7-H3.TLT-2 信号传导会降低 TLT-2。

项目成果

Enhancement of effector CD8^+ T cell function by tumor-associated B7-H3 and modulation of its counter receptor triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) at tumor sites.

通过肿瘤相关的 B7-H3 增强效应 CD8^ T 细胞功能，并调节其反受体触发肿瘤部位骨髓细胞样转录物 2 (TLT-2) 上表达的受体。

• 发表时间: 2010
• 作者: Kobori H;Hashiguchi M;Azuma M
• 通讯作者: Azuma M

Tumor-infiltrating CD8+ T cells express TLT-2, a counter receptor for B7-H3 and B7-H3-transduced tumors preferentially augment effector function of CD8^+ T cells

肿瘤浸润 CD8 T 细胞表达 TLT-2，这是 B7-H3 的反受体，B7-H3 转导的肿瘤优先增强 CD8^ T 细胞的效应功能

• 发表时间: 2009
• 作者: H.Kobori;M.Hashiguchi;M.Azuma.
• 通讯作者: M.Azuma.

Analyses of anti-tumor immunity enhanced by a B7-H3 costimulator.

B7-H3 共刺激剂增强抗肿瘤免疫的分析。

• 发表时间: 2009
• 作者: Kobori H;Hashiguchi M;Piao J;Azuma M
• 通讯作者: Azuma M

Triggering receptor expressed on myeloid cells-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses in mice and humans.

骨髓细胞样转录物 2 (TLT-2) 上表达的触发受体是 B7-H3 的反受体，可增强小鼠和人类的 T 细胞反应。

• 发表时间: 2010
• 作者: Hashiguchi M;Kobori H;Ritprajak P;Kamimura Y;Azuma M
• 通讯作者: Azuma M

Binding property, expression, and function of human TLT2, a counter-receptor for B7-H3

人 TLT2（B7-H3 的反受体）的结合特性、表达和功能

• 发表时间: 2009
• 作者: Hashiguchi M;Kobori H;Azuma M
• 通讯作者: Azuma M