Development of regenerative medicine for periapical bone defect

点击翻译按钮获取中文摘要

Pulpotomy was performed in the mandibular first molars of rats, and then bFGF or VitapexR(VIT) containing calcium hydroxide were applied to the exposed pulp tissues. In the bFGF-treated rats, cells expressing TGF-β1 or BMP-2 rapidly increased in number, and newly formed reparative dentin was observed earlier and larger in amount than that seen in the VIT-treated rats. It is suggested that there may be a difference in the time and extent of expression of cytokine and growth factors between bFGF and VIT-treated rats.Active new bone formation was observed in the bone defect with a combination of bFGF and Bioactive glass(BAG). It is speculated that BAG was a useful biomaterial with high bone conductivity.