A Histopathological Study on the Effect of Indomethacin on Bone Resorption in an Experimental Apical Periodontitis

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The effect of indomethacin (10mg/Kg/day) on bone resorption was investigated on an experimental apical periodontitis induced in wistar strain rats. Indomethacin reduced the extent of resorption surface, the number of osteoclasts, and the number of non-specific acid phosphatase (ACP) positive cells. ACP activity in the osteoclasts was decreased considerably. In addition, the infiltration of polymorphonuclear leucocytes in the apical periodontal ligament was hardly seen after the administration of Indomethacin. But the extent of formation surface was significantly increased. These results suggest that the relationship between bone resorption and formation in apical periodontis is a coupling phenomenon, and PG may stimulate osteoclastics bone resorption.