A Histopathological Study on the Effect of Indomethacin on Bone Resorption in an Experimental Apical Periodontitis

消炎痛对实验性根尖周炎骨吸收影响的组织病理学研究

• 批准号: 62570857
• 负责人: ANAN Hisashi
• 金额: $ 1.34万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570857/
• 关键词: Indomethacin; Bone resorption; Apical periodontitis; Osteoclast; Acid phosphatase; 骨芽細胞; アルカリフォスファターゼ; カップリング現象; 酸フォスファターゼ; エステラーゼ; プロスタグランディン合成酵素

The effect of indomethacin (10mg/Kg/day) on bone resorption was investigated on an experimental apical periodontitis induced in wistar strain rats. Indomethacin reduced the extent of resorption surface, the number of osteoclasts, and the number of non-specific acid phosphatase (ACP) positive cells. ACP activity in the osteoclasts was decreased considerably. In addition, the infiltration of polymorphonuclear leucocytes in the apical periodontal ligament was hardly seen after the administration of Indomethacin. But the extent of formation surface was significantly increased. These results suggest that the relationship between bone resorption and formation in apical periodontis is a coupling phenomenon, and PG may stimulate osteoclastics bone resorption.

本文观察了消炎痛（10 mg/Kg/d）对Wistar大鼠实验性根尖周炎骨吸收的影响。吲哚美辛减少了吸收表面的程度，破骨细胞的数量和非特异性酸性磷酸酶（ACP）阳性细胞的数量。破骨细胞中ACP活性显著降低。此外，消炎痛治疗后，根尖牙周膜内几乎没有多形核白细胞浸润。但地层表面的范围明显增加。提示根尖周炎时骨吸收与骨形成之间存在耦合关系，PG可能刺激破骨细胞的骨吸收。