Molecular design of amylase inhibitor based on the substrate recognition property of the enzyme

抑制胰腺α-淀粉酶对于肥胖和糖尿病的治疗是有用的。然而，这种酶的小分子抑制剂并不是很多，因为它具有识别链状葡萄糖的底物识别特性。我们利用底物识别的这种特征模式设计了新的小分子α-淀粉酶抑制剂，并进行了合成。这些合成的抑制剂揭示了胰腺α-淀粉酶的一个有用的性质，为进一步开发该抑制剂奠定了基础。

Inhibition of the pancreaticα-amylase is useful for the treatment of obesity and diabetes mellitus. However, not many small molecule inhibitors are known for this enzyme due to its characteristic substrate recognition which recognizes chained glucoses. We used this characteristic mode of substrate recognition to design new small moleculeα-amylase inhibitors and synthesized them. These synthetic inhibitors revealed a useful property of the pancreaticα-amylase for further development of the inhibitor.