Studies on the mechanisms of anticancer and anti-inflammatory activities of alkaloids from ascidians

Lissoclibadins是从印度尼西亚殖民海鞘中分离的抗癌生物碱，通过增加半胱天冬酶（诱导细胞凋亡的重要蛋白质）的活性来诱导癌细胞的细胞凋亡（程序性细胞死亡）。从西表群岛采集的海绵中分离出两种生物碱，冲绳作为细胞毒成分，诱导癌细胞凋亡。DDMG-1是一种从印度尼西亚孤生海鞘中分离的生物碱，可降低TNF-α的产生，TNF-α是一种在风湿病和癌症中过度产生的炎性细胞因子，并阐明了其作用的分子机制。从一种印度尼西亚软珊瑚中分离出三种抑制TNF-α产生的组分。

Lissoclibadins, anticancer alkaloids isolated from an Indonesian colonial ascidian, induced an apoptosis(programmed cell death) to cancer cells by increasing the activity of caspases, important proteins for the induction of an apoptosis. Two alkaloids were isolated from a sponge collected in Iriomote Is., Okinawa as cytotoxic components, which induced an apoptosis to cancer cells. DDMG-1, an alkaloid isolated from an Indonesian solitary ascidian, decreased the production of TNF-α, an inflammatory cytokine that over produced in rheumatism and cancer, and the molecular mechanism of action was elucidated. Three components, which inhibited the production of TNF-α, were isolated from an Indonesian soft coral.