Studies on the mechanisms of anticancer and anti-inflammatory activities of alkaloids from ascidians

Lissoclibadins是一种从印度尼西亚殖民地海鞘中分离出来的抗癌生物碱，它通过增加caspase的活性来诱导癌细胞凋亡(程序性细胞死亡)，caspase是诱导细胞凋亡的重要蛋白质。从采自冲绳县伊里奥莫特的海绵中分离得到两种生物碱，作为细胞毒性成分，诱导癌细胞凋亡。从印度尼西亚孤立的海鞘中分离得到的生物碱DDMG-1可减少风湿病和癌症中过度产生的炎性细胞因子肿瘤坏死因子-α的产生，并阐明了其作用的分子机制。从印度尼西亚的一种软珊瑚中分离出三种抑制肿瘤坏死因子-α产生的成分。

Lissoclibadins, anticancer alkaloids isolated from an Indonesian colonial ascidian, induced an apoptosis(programmed cell death) to cancer cells by increasing the activity of caspases, important proteins for the induction of an apoptosis. Two alkaloids were isolated from a sponge collected in Iriomote Is., Okinawa as cytotoxic components, which induced an apoptosis to cancer cells. DDMG-1, an alkaloid isolated from an Indonesian solitary ascidian, decreased the production of TNF-α, an inflammatory cytokine that over produced in rheumatism and cancer, and the molecular mechanism of action was elucidated. Three components, which inhibited the production of TNF-α, were isolated from an Indonesian soft coral.