Functional and anatomical connectivity study using fMRI and DTI

使用 fMRI 和 DTI 进行功能和解剖连接研究

• 批准号: 21613002
• 负责人: IIDAKA Tetsuya
• 金额: $ 3.08万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21613002/
• 关键词: fMRI; DTI; 白質; 線維連絡; 高次脳機能; 社会脳; 自閉症; 脳賦活検査; FA; 脳賦活

Functional and structural investigations of neuroanatomical substrates that correlate with autistic tendency in healthy human subjects are critical for understanding autism-spectrum disorder. To accomplish this, we performed functional magnetic resonance imaging(fMRI) in combination with diffusion tensor imaging(DTI) in 30 healthy young subjects. The subjects were evaluated using the Autistic-Spectrum Quotient(AQ), which was designed to measure autistic traits in both healthy and autistic subjects. Face specific brain activation in the superior temporal sulcus(STS) and amygdala(AMG) was identified using fMRI and passive viewing of faces. In addition, probabilistic tractography performed in each subject by using DTI showed a white matter pathway between the STS and AMG regions. The volume of connectivity between these regions correlated positively with the total AQ score(Spearman's rho=0. 38, p<0. 05). These results suggest that healthy subjects with high autistic traits may show an increase in the white matter pathway that connects key regions involved in face processing.

在健康的人类受试者中，与自闭症倾向相关的神经解剖学基底的功能和结构研究对于理解自闭症谱系障碍是至关重要的。为了实现这一点，我们进行了功能磁共振成像（fMRI）结合扩散张量成像（DTI）在30名健康的年轻受试者。研究人员使用自闭症谱系商数（AQ）对受试者进行评估，AQ旨在测量健康受试者和自闭症受试者的自闭症特征。面部特异性脑激活的上级颞沟（STS）和杏仁核（AMG）被确定使用功能磁共振成像和被动观看的面孔。此外，通过使用DTI对每个受试者进行的概率纤维束成像显示STS和AMG区域之间存在白色物质通路。这些区域之间的连接量与总AQ评分呈正相关（斯皮尔曼rho=0. 38，p<0. 05）。这些结果表明，具有高度自闭症特征的健康受试者可能显示出连接涉及面部处理的关键区域的白色物质通路的增加。

项目成果

White matter connectivity between superior temporal sulcus and amygdala is associated with empathetic ability in normal humans

颞上沟和杏仁核之间的白质连接与正常人的共情能力有关

• 发表时间: 2011
• 作者: T.IIDAKA;T.NAKAI;T.HARADA;M.MIYAKOSHI
• 通讯作者: M.MIYAKOSHI

White matter connectivity between superior temporal sulcus and amygdalais associated with empathetic ability in normal humans

颞上沟和杏仁核之间的白质连接与正常人的共情能力相关

• 发表时间: 2011
• 作者: T. IIDAKA;T. NAKAI;T. HARADA;M. MIYAKOSHI
• 通讯作者: M. MIYAKOSHI

脳機能検索法の未来「情動の機能を脳画像で探る」

大脑功能搜索方法的未来“利用大脑图像探索情感功能”

• 发表时间: 2010
• 作者: Odaka K;Minamino T;et al;飯高哲也
• 通讯作者: 飯高哲也

White matter connectivity between superior temporal sulcus and amygdala is associated with autistic trait in healthy humans

• DOI: 10.1016/j.neulet.2012.01.029
• 发表时间: 2012-02-29
• 期刊: NEUROSCIENCE LETTERS
• 影响因子: 2.5
• 作者: Iidaka, Tetsuya;Miyakoshi, Makoto;Nakai, Toshiharu
• 通讯作者: Nakai, Toshiharu