The possibility of the gut flora as a new health index-validation from the association between exercise, lifestyle and the gut flora

肠道菌群作为新的健康指标的可能性——从运动、生活方式与肠道菌群的关系验证

• 批准号: 21650178
• 负责人: UMEDA Takashi
• 金额: $ 2.19万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21650178/
• 关键词: 住民健診; 健康指標; 応用健康科学; 生活習慣病; 腸内細菌

The simple measuring method of the gut flora using the molecular biological technique was developed recently. We examined the characteristic of the expression patterns of the gut flora using this method in general populations.We verified whether observing the expression patterns of the gut flora would be effective as new health indicator and a screening index of a lifestyle-related disease. We examined all survey contents in this study with the result of the health-check up in the Iwaki Health Promotion Project.The expression ratio of OTU332 (lactic acid bacterium) in the lean person group was significantly higher than those in the obesity group and the standard group in this result. This result suggested that obesity was significantly related to the expression patterns of gut flora, and it was one of the lifestyle-related diseases and the main risk factor of the lifestyle-related disease. This result suggested that a lactic acid bacterium might become the obese protective factors.In addition, we are considered and analyzing in details now about the associations between lifestyle related diseases expect for obesity and the expression pattern of gut flora.

最近开发了使用分子生物技术的肠道菌群的简单测量方法。我们使用该方法在一般人群中检查了肠道菌群的表达模式的特征。我们验证观察肠道菌群的表达模式是否有效，作为新的健康指标和与生活方式相关疾病的筛查指数。我们检查了本研究中的所有调查内容，并在伊瓦基健康促进项目中进行了健康检查结果。瘦人组的OTU332（乳酸细菌）的表达比显着高于肥胖组和该结果中标准组的表达比。该结果表明肥胖与肠道菌群的表达模式显着相关，它是与生活方式有关的疾病之一，也是与生活方式相关疾病的主要危险因素。该结果表明，乳酸细菌可能成为肥胖的保护因素。此外，我们正在考虑并分析有关生活方式相关疾病对肥胖症和肠道菌群表达模式之间关联的详细信息。

项目成果

Effect of alcohol drinking and cigarette smoking on neutrophil functions in adults

饮酒和吸烟对成人中性粒细胞功能的影响

• 发表时间: 2011
• 期刊: Luminescence
• 影响因子: 2.9
• 作者: Sato J;Takahashi I;Umeda T;Matsuzaka M;Danjyo K;Tsuya R;Kida K;Takami H;Nakaji S
• 通讯作者: Nakaji S

Effect of human gut microbiota on methane production

人类肠道微生物群对甲烷产生的影响

• 发表时间: 2011
• 期刊: Hirosaki Med J
• 作者: Hasebe T;Umeda T;Danjo K;Takahashi I;Matsuzaka M;Kudo J;Semato M;Saito Y;Hisada T;Benno Y;Nakaji S;Hakamada K
• 通讯作者: Hakamada K

The Relationship Between Serum Selenium Concentration and Neutrophil Function in Peripheral Blood

• DOI: 10.1007/s12011-011-9108-8
• 发表时间: 2011-12-01
• 期刊: BIOLOGICAL TRACE ELEMENT RESEARCH
• 影响因子: 3.9
• 作者: Lee, Sangun;Takahashi, Ippei;Nakaji, Shigeyuki
• 通讯作者: Nakaji, Shigeyuki

一般住民の腸管内メタン産生と腸内細菌に関する研究

一般人群肠道甲烷产生和肠道细菌的研究

• 发表时间: 2010
• 作者: 長谷部達也;梅田孝;工藤淳子;狭戸尾真梨子;齋藤百合子;浜田菜穂子;船橋浩一;中路重之
• 通讯作者: 中路重之

自記式睡眠評価とメタボリックシンドロームの関係

自我报告的睡眠评估与代谢综合征之间的关系

• 发表时间: 2012
• 作者: 長谷部達也;梅田孝;工藤淳子;狭戸尾真梨子;齋藤百合子;浜田菜穂子;船橋浩一;中路重之;大久保礼由,松坂方士,佐藤真樹,小嶋新太,兼板佳孝,大井田隆,梅田孝,中路重之
• 通讯作者: 大久保礼由,松坂方士,佐藤真樹,小嶋新太,兼板佳孝,大井田隆,梅田孝,中路重之