Regulation of growth-plate chondrocyte differentiation by self-produced secreted and membrane proteins

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This is the study to screen proteins with signal sequence at their N-terminus produced by growth-plate chondrocytes to find key molecules to regulate chondrocyte differentiation by autocrine/ paracrine mechanisms. More than 70 of secreted and membrane proteins were identified by SST-REX method. We focused on secreted protein IGFBP5 and membrane protein FGFR5, and found that these proteins were expressed at specific stage during the differentiation in vivo and in vitro.