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Basic study on viral genome related to pathogenesis of SHIV infection in non-human primate AIDS model

Basic study on viral genome related to pathogenesis of SHIV infection in non-human primate AIDS model
非人灵长类艾滋病模型中SHIV感染发病机制相关病毒基因组基础研究
批准号:
21300152
负责人:
MIURA Tomoyuki
金额:
$10.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Highly pathogenic SHIV-KS661 was switched from CXCR4-tropic virus to CCR5-tropic by adding five amino acid substitutions to the env-V3 domain, which isthe co-receptor determinant of the virus. The virus was adapted to rhesus monkey and neutralization-resistant CCR5-tropic SHIV-MK38 was obtained by in vivo passages. The envregion of the virus was successfully introduced into new monkey tropic HIV-1mt. These results will contribute to establish a better AIDS model.
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Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge.
猿猴免疫缺陷病毒攻击后,显着诱导疫苗抗原特异性细胞毒性 T 淋巴细胞反应。
DOI: 10.1016/j.bbrc.2011.04.071
发表时间: 2011
期刊: Biochemical and Biophysical Research Communications
影响因子: 3.1
作者: [Takahara, Y.]
通讯作者: Y.
DOI: 10.1016/j.imlet.2009.03.007
发表时间: 2009-04-27
期刊: IMMUNOLOGY LETTERS
影响因子: 4.4
作者: [Iwami, Shingo, Nakaoka, Shinji, Miura, Tomoyuki]
通讯作者: Miura, Tomoyuki
No viral Evolution in the lymph Nodes of Simian Immunodecifiency Virus-Infected Rhesus Macaaues during Combined Antiretroviral Therapy
联合抗逆转录病毒治疗期间感染猿猴免疫缺陷病毒的恒河猴淋巴结无病毒进化
DOI: 10.1128/jvi.03367-12
发表时间: 2013
期刊: J Virol
影响因子: 5.4
作者: [Oue M, et al.]
通讯作者: et al.
Major histocompatibility complex class I-restricted cytotoxic T 1 lymphocyte responses during primary simian immunodeficiency virus infection in Burmese rhesus macaques.
缅甸恒河猴原发性猿猴免疫缺陷病毒感染期间主要组织相容性复合物 I 类限制细胞毒性 T 1 淋巴细胞反应。
DOI: 10.1111/j.1348-0421.2011.00384.x
发表时间: 2011
期刊: Microbiol. Immunol.
影响因子: --
作者: [Nakamura, M.]
通讯作者: M.
23
    Empirical study on the formation of AIDS pathogenesis by primate model
    • 批准号:
      16H04682
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.4万
    • 财政年份:
      2016
    • 负责人:
      MIURA Tomoyuki
    • 依托单位:
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    • 批准号:
      23658240
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2011
    • 负责人:
      MIURA Tomoyuki
    • 依托单位:
    Study for molecular basis of AIDS pathogenesis on non-human primate model
    • 批准号:
      18300142
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.58万
    • 财政年份:
      2006
    • 负责人:
      MIURA Tomoyuki
    • 依托单位:
    Taxonomical study of deep sea polychaetes and vestimentiterans from Indo-Pacific Ocean
    • 批准号:
      14540646
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2002
    • 负责人:
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    • 依托单位:
    海外基金