A safety evaluation study on dietary fat in the miniature pig. Focusing on the endocrine disrupting effect.

食用菜籽油可缩短卒中易发自发性高血压大鼠的寿命。在这项研究中，我们检查了食用菜籽油对小型猪的影响。断奶后18个月，在饲粮中按10w/w%添加菜籽油或大豆油（作为对照）。然后对这些动物进行解剖。精子小管中生殖细胞数量减少。通过DNA微阵列技术检测睾丸和肾上腺中的基因表达，揭示了可能对类固醇激素代谢的影响。

Canola oil ingestion shortens the life-span of stroke-prone spontaneously hypertensive rats(SHRSP). In this study we examined the effects of canola oil ingestion in miniature pigs. Miniature pigs were given canola oil or soybean oil(as the control) at 10w/w% in diet for 18 months from weaning. The animals were then autopsied. Decreased number of germ cells in the seminiferous tubule was found. Gene expression in the testis and the adrenal gland examined by means of DNA microarray technique revealed a possible influence on the metabolism of steroid hormones.