Selfish DNases at a diverging point to survival, death and evolution

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Our experimental analyses and genome comparisons revealed how DNAases distinguishing self and non-self genome acted on genomes and drove their evolution.1. We revealed role of antisense RNA in their gene regulation and life cycle.2. We showed several restriction enzymes cleave a DNA replication fork.3. With restriction enzyme attacking the chromosome, we demonstrated success of suicidal defense strategy against infection.4. Genome comparison of H. pylori revealed novel mechanisms of genome rearrangements and suggested that restriction modification systems frequently switch their recognition sequence.