Structural analysis of A1 protein-telomere-telomerase complex, and development of inhibition of telomerase

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We have determined the structure of the Musashi-target RNA binary complex with the assist of long-range structural information. With the same assist, the structure of the A1 protein-telomere DNA-telomerase RNA ternary complex has been analyzed. It has been shown that A1 works as a bridge between telomere DNA and telomerase RNA. This suggests that A1 functions to bring telomerase to telomere DNA. The strategy to inhibit telomerase with decoy nucleic acids has also been suggested to be promising.