Molecular mechanism of the desiccation tolerance induced by trehalose and LEA proteins in anhydrobiotic organisms
Molecular mechanism of the desiccation tolerance induced by trehalose and LEA proteins in anhydrobiotic organisms
批准号:
21370068
负责人:
SAKURAI Minoru
金额:
$11.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We have revealed some of the molecular mechanisms responsible for the desiccation tolerance of anhydrobiotic organisms such as Polypedilum vanderplanki. Fisrt is the structuralization of LEA proteins in the dry state and their vitrification with trehalose(steel-reinforced concrete model). Second is the ion-scavenger effect of LEA proteins and their anti-aggregation effect against on proteins during desiccation. Furthermore, we have obtained the invaluable information about the substrate transport mechanism of trehalose transporter.
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Model Study of the Desiccation-induced Vitrification of Group-3 Late Embrogenesis Abundant Proteins
Group-3胚胎发生晚期丰富蛋白干燥诱导玻璃化的模型研究
DOI:
--
发表时间:
2010
期刊:
Cryobiol.Cryotech. 56
影响因子:
--
作者:
[Furuki, T.Shimizu, T., Takahashi, T., Mihara, H., Kikawada, T., Okuda, T., Sakurai, M.]
通讯作者:
M.
モデルペプチドを用いたLEA(Late Embryogenesis Abundant)タンパク質の分子構造とガラス化に与える塩濃縮効果の検討
使用模型肽检查 LEA(胚胎发育晚期)蛋白的分子结构和盐浓度对玻璃化冷冻的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[上田太郎, 祐村恵彦, 長崎晃, 古木隆生,清水天平,黄川田隆洋,奥田隆,高橋剛,三原久和,櫻井実]
通讯作者:
古木隆生,清水天平,黄川田隆洋,奥田隆,高橋剛,三原久和,櫻井実
DOI:
10.1021/bi200719s
发表时间:
2011-08-23
期刊:
BIOCHEMISTRY
影响因子:
2.9
作者:
[Furuki, Takao, Shimizu, Tempei, Sakurai, Minoru]
通讯作者:
Sakurai, Minoru
LEAタンパク質のモデルペプチドが示す分子構造及びガラス転移の含水率依存性
LEA 蛋白模型肽显示的分子结构和玻璃化转变的水含量依赖性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[中嶋潤, 梅木伸久, 上田太郎, 古木隆生,清水天平,黄川田隆洋,奥田隆,櫻井実]
通讯作者:
古木隆生,清水天平,黄川田隆洋,奥田隆,櫻井実
グループ3LEAタンパク質の22-merモデルペプチドが示すタンパク質凝集抑制効果
第 3 组 LEA 蛋白的 22 聚体模型肽显示的蛋白聚集抑制作用
DOI:
--
发表时间:
2011
期刊:
低温生物工学会誌
影响因子:
--
作者:
[古木隆生, 清水天平, S. Charkrabortee, 畑中理恵, 高橋剛, 黄川田隆洋, 奥田隆, 三原久和, A. Tunnacliffe, 櫻井実]
通讯作者:
櫻井実
共 20 条
Elucidation of biological functions of LEA proteins as a desiccation protectant and their industrial application
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批准号:24370065
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.48万
-
财政年份:2012
-
负责人:SAKURAI Minoru
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依托单位:
Computional study of the spectral tuning and photoreaction of photoactive yellow protein
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批准号:12680653
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:SAKURAI Minoru
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依托单位:
Effect of anti-sense P-glycoprotein oligomer on P-glycoprotein-positive multidrug-resistant cancers
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批准号:05454287
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1993
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负责人:SAKURAI Minoru
-
依托单位:
STUDY ON EFFECTIVE COMBINATION AND ENHANCED EFFECTS OF ANTICANCERDRUGS
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批准号:60440050
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$11.01万
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财政年份:1985
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负责人:SAKURAI Minoru
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依托单位:
海外基金