Study of molecular coordination between nuclear and mitochondrial replications.

核和线粒体复制之间的分子协调研究。

• 批准号: 21370076
• 负责人: HIGASHITANI Atsushi
• 金额: $ 12.06万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21370076/
• 关键词: オルガネラ; チェックポイント制御; 複製; ミトコンドリア; ATR; オートファジー; SOD; 寿命; ストレス応答; チェックポイント; 細胞周期; ミトコンドリア複製; ミトコンドリアDNA; Ataxia; ATM/ATR; 蛋白質相互作用; レトログレードシグナル; DNA複製; DNA損傷; 酸化ストレス; ATM

ATR is highly conserved in all eukaryotes and functions as a cell-cycle nuclear checkpoint kinase. In mammals, ATR hypomorphic mutation causes a complex disease known as Seckel syndrome. However, molecular mechanisms that cause a wide variety of symptoms including accelerated aging have remained unclear. We here found that in the nematode Caenorhabditis elegans, a deletion mutant of ATR atl-1 achieved longevity. Transcription levels of certain superoxide dismutase genes significantly increased in the mutant. In addition, mammalian ATR over-expression induced autophagic cell death.

ATR在所有真核生物中高度保守，并作为细胞周期核检查点激酶发挥作用。在哺乳动物中，ATR亚型突变导致称为Seckel综合征的复杂疾病。然而，导致包括加速老化在内的各种症状的分子机制仍不清楚。我们在这里发现，在线虫秀丽隐杆线虫中，ATR atl-1的缺失突变体实现了长寿。某些超氧化物歧化酶基因的转录水平显着增加的突变体。此外，哺乳动物ATR过表达诱导自噬细胞死亡。

项目成果

Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner

• DOI: 10.1242/jcs.052415
• 发表时间: 2009-10
• 期刊: Journal of Cell Science
• 影响因子: 4
• 作者: Yohei Sasagawa;M. Otani;N. Higashitani;A. Higashitani;Ken Sato;T. Ogura;K. Yamanaka

Biological responses to ionizing radiation in the nematode C.elegans

线虫对电离辐射的生物反应 C.elegans

• 发表时间: 2012
• 作者: 鮫島知哉、船津高志;ら;東谷篤志
• 通讯作者: 東谷篤志

C.elegans as a model organism for understanding the effects of spaceflight

线虫作为了解太空飞行影响的模式生物

• 发表时间: 2011
• 作者: Higashitani;A.;Higashibata;A.
• 通讯作者: A.

Auxins reverse plant male sterility caused by high temperatures

• DOI: 10.1073/pnas.1000869107
• 发表时间: 2010-05-11
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Sakata, Tadashi;Oshino, Takeshi;Higashitani, Atsushi
• 通讯作者: Higashitani, Atsushi

Localization of X-ray cross complementing gene 1 protein in the nuclear matrix is controlled by casein kinase II-dependent phosphorylation in response to oxidative damage

• DOI: 10.1016/j.dnarep.2009.06.003
• 发表时间: 2009-08-06
• 期刊: DNA REPAIR
• 影响因子: 3.8
• 作者: Kubota, Yoshiko;Takanami, Takako;Horiuchi, Saburo
• 通讯作者: Horiuchi, Saburo