Establishment of novel non-invasive test for differential diagnosis and severity evaluation of hepatobiliary diseases in dogs and cats.

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(1) Both Dynamic-CT and CEU using new contrast agent SONAZOID are useful for distinguish benign and malignant, hapatocellular carcinoma and other malignant tumors. These non-invasive diagnostic imaging, especially SONAZOID-CEU will be important tools in veterinary clinical field in the future.(2) The expression of 9 fibrosis-related genes showed significant positive correlation with the degree of canine liver fibrosis, indicating the similar molecular regulation with human and mouse. Results suggest that the gene expression analysis using liver tissue sample could be a useful tool for evaluating the degree of fibrosis in dogs.(3) Measurement of the blood Blood hyaluronic acid(HA) concentration of dogs with suspected liver disease can be a useful diagnostic aid for canine cirrhosis.(4) Gallbladder ejection fraction estimated by ultrasonography was easy and useful as the index of gallbladder emptying. In this study, we firstly found that biliary stasis occurs not only in dogs with gallbladder mucocele but also in dogs with biliary sludge.