Physiological functions of secreted phospholipase A_2 enzymes

为了探讨分泌型磷脂酶A2(SPLA2)在体内的功能，我们对SPLA2基因敲除小鼠和转基因小鼠进行了分析。我们发现：(1)两个SPLA2，III和X，分别调节男性生殖道中精子的成熟和激活；(2)SPLA2；2-GT；X调节毛发内稳态、胃肠道脂肪消化和神经功能；(3)树突状细胞特异性亚型SPLA2参与接触性超敏反应的解决；以及(4)饮食诱导脂肪细胞来源的SPLA2在改善代谢综合征中发挥作用。

To explore the in vivo functions of secreted phospholipase A_2s(sPLA_2s), we analyzed knockout and transgenic mice for individual sPLA_2 isoforms. We found that(1) the two sPLA_2s, III and X, respectively regulates sperm maturation and activation in male genital tracts ;(2) sPLA_<2-> X regulates hair homeostasis, gastrointestinal lipid digestion, and neuronal functions ;(3) sPLA_<2-> IID, a dendritic cell-specific isoform, participates in resolution of contact hypersensitivity ; and(4) sPLA_<2-> V, a diet-inducible adipocyte-derived sPLA_2, plays a role in amelioration of metabolic syndrome.