Physiological functions of secreted phospholipase A_2 enzymes

为了探索分泌磷脂酶a2s （spla2s）在体内的功能，我们分析了敲除和转基因小鼠对sPLA_2亚型的影响。研究发现：(1)两个sPLA_2s， III和X分别调控男性生殖道中精子的成熟和激活；(2) sPLA_<2-> X调节毛发稳态、胃肠道脂质消化和神经元功能；(3)树突状细胞特异性异构体sPLA_<2-> IID参与接触超敏反应的解决；(4)饮食诱导的脂肪细胞源性sPLA_2 <2-> V对代谢综合征有改善作用。

To explore the in vivo functions of secreted phospholipase A_2s(sPLA_2s), we analyzed knockout and transgenic mice for individual sPLA_2 isoforms. We found that(1) the two sPLA_2s, III and X, respectively regulates sperm maturation and activation in male genital tracts ;(2) sPLA_<2-> X regulates hair homeostasis, gastrointestinal lipid digestion, and neuronal functions ;(3) sPLA_<2-> IID, a dendritic cell-specific isoform, participates in resolution of contact hypersensitivity ; and(4) sPLA_<2-> V, a diet-inducible adipocyte-derived sPLA_2, plays a role in amelioration of metabolic syndrome.