Quality control mechanisms of cargo proteins in the post-Golgi trafficking

为了阐明高尔基体/内体定位的网格蛋白衔接子，GGA和AP 1的生理功能，我们进行了广泛的功能分析，使用哺乳动物和果蝇模型系统。我们发现，GGAs和AP 1分别参与表皮生长因子受体和Notch的细胞内运输，通过逃避它们的降解。因此，我们提出了GGA/AP 1在细胞增殖和分化中的新功能，这将可能有助于开发新的癌症治疗方法。

To elucidate physiological functions of Golgi/endosome-localized clathrin adaptors, GGAs and AP1, we performed extensive functional analysis using mammalian and drosophila model systems. We found that GGAs and AP1 are involved in the intracellular trafficking of epidermal growth factor receptor and Notch, respectively, by evading their degradations. Therefore, we propose new function of GGAs/AP1 in cell proliferation and differentiation, which would potentially be useful for developing new cancer therapy.