Functional analyses of receptor tyrosine kinases, Ror1 and Ror2, in Wnt signalin

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In mammals, including humans, binding of an secreted protein, Wnt5a, to its cognate receptors, the receptor tyrosine kinases, Ror1 and Ror2, elicits intracellular signalings that play important roles in the morphogenesis of tissues and organs during the developmental processes. In this study, we have shown that Wnt5a-Ror1/Wnt5a-Ror2 signalings play important roles in the morphogenesis of tissues and organs by regulating cell polarity and migration, and have elucidated the relationship between abnormalities in these signalings and developmental anomalies and cancer invasion.