Abnormal NKG2D ligand expression and disease

NKG2D配体是主要组织相容性复合体I类分子，其表达由细胞应激（如转化和病毒感染）诱导。它们作为危险信号，提醒免疫系统存在不健康的应激细胞。在本研究中，我们分析了NKG2D配体的结构和功能，以及它们在病理过程中的作用，重点分析了我们实验室鉴定的小鼠NKG2D配体H60c。

NKG2D ligands are major histocompatibility complex class I-like molecules whose expression is induced by cellular stresses such as transformation and viral infections. They function as danger signals alerting the immune system to the presence of unhealthy, stressed cells. In the present study, we analyzed the structure and function of NKG2D ligands, and their role in pathologic processes, with emphasis on the analysis of H60c, a mouse NKG2D ligand identified in our laboratory.