Development of a novel"Seed and Soil"cardiac regenerative strategy with ES/iPS cells

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In this study, we tried to develop a new efficient cardiac regenerative strategy with a combinatory exploration of transplantable cell sources(seeds) and efficient differentiation environments(soil). We succeeded in inducing cardiomyocytes from human iPS cells using cyclospolin-A(PLoS One, 2011a), developing an efficient differentiation method and purification method for cardiomyocytes from human iPS cells(PLoS One, 2011b). We also showed the potentials and mechanisms of cardiac tissue sheet transplantation in cardiac function after myocardial infarction. Transplantation of the cardiac tissue sheet to a rat myocardial infarction model showed significant and sustained improvement of systolic function accompanied by neovascularization(Stem Cells, 2012). Currently, we identified a novel small compound from marine sponge showing potent cardiomyocyte inducing effect. Thus, we succeeded in establishing a technological basis for"Seed and soil"cardiac regenerative strategy.