Functional Roles of Nuclear Matrix Binding Factors in Major Tumor Suppressor Pathways in Human

核基质结合因子在人类主要肿瘤抑制途径中的功能作用

• 批准号: 21390502
• 负责人: IKEDA Masaaki
• 金额: $ 11.65万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390502/
• 关键词: 実験腫瘍学; 癌抑制遺伝子; p53; RB; 分子生物学; 細胞周期; アポトーシス; 核内高次機能; 核マトリクス結合因子

The pathways regulated by p53 and RB tumor suppressors and TGF-βsignaling play important roles in tumor suppression in human. In this study, we investigated the functional roles of DRIL1 and its closely related DRIL2, family members of ARID(AT-rich interaction domain) DNA-binding proteins, in three major tumor suppressor pathways. We found that DRIL1 cooperates with p53 to activate pro-arrest p21^<WAF1> transcription, and that DRIL1 and DRIL2 play important roles in E2F-target gene expression and cell cycle progression. In addition, our results suggest that DRIL2 function is required for osteogenic differentiation. These results provide important insights in the regulation of human tumor suppressor pathways.

P53、Rb抑癌基因和转化生长因子-β信号转导通路在人类肿瘤抑制中起着重要作用。在这项研究中，我们研究了DRIL1及其密切相关的DRIL2家族成员在三条主要的肿瘤抑制途径中的功能。我们发现DRIL1与P53协同激活p21；；WAF1&gt；转录，并且DRIL1和DRIL2在E2F靶基因表达和细胞周期进程中起重要作用。此外，我们的结果提示DRIL2功能是成骨分化所必需的。这些结果为人类肿瘤抑制通路的调控提供了重要的见解。

项目成果

Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential

• DOI: 10.1073/pnas.1011054107
• 发表时间: 2010-11
• 期刊: Proceedings of the National Academy of Sciences
• 作者: Yoshinori Ohno;S. Yasunaga;M. Ohtsubo;Sayaka Mori;M. Tsumura;S. Okada;T. Ohta;K. Ohtani;Masao Kobayashi;Y. Takihara

Drug-specific Effects of Caspase-8 and p53/p73 Alterations on Chemo sensitivity in Head and Neck Carcinoma Cells

Caspase-8 和 p53/p73 改变对头颈癌细胞化疗敏感性的药物特异性影响

• 发表时间: 2009
• 作者: Juan Liu;Nobuo Tsuchida;Masa-Aki Ikeda
• 通讯作者: Masa-Aki Ikeda

卵胞細胞特異的SF-1ノックアウトマウスの卵巣分化

卵泡细胞特异性SF-1敲除小鼠的卵巢分化

• 发表时间: 2009
• 作者: Senpuku H;Yoneda S;Narisawa N;Kawarai T;Sato Y;Ochiai K;Watanabe H;池田やよい
• 通讯作者: 池田やよい

Inability of Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient for p53Ser46 phosphorylation

Nutlin-3 和 RITA 无法克服 p53Ser46 磷酸化缺陷的肿瘤细胞中的 p53 耐药性

• 发表时间: 2011
• 作者: Teng Ma;Shumpei Yamada;Solachuddin J. A Ichiwan;Kiyoshi Ohtani;Megumi Ostu;Masa-Aki Ikeda
• 通讯作者: Masa-Aki Ikeda

Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer

• DOI: 10.1016/j.oraloncology.2009.05.638
• 发表时间: 2009-10-01
• 期刊: ORAL ONCOLOGY
• 影响因子: 4.8
• 作者: Murugan, Avaniyapuram Kannan;Hong, Nguyen Thi;Tsuchida, Nobuo
• 通讯作者: Tsuchida, Nobuo