Functional Roles of Nuclear Matrix Binding Factors in Major Tumor Suppressor Pathways in Human

P53、Rb抑癌基因和转化生长因子-β信号转导通路在人类肿瘤抑制中起着重要作用。在这项研究中，我们研究了DRIL1及其密切相关的DRIL2家族成员在三条主要的肿瘤抑制途径中的功能。我们发现DRIL1与P53协同激活p21；；WAF1&gt；转录，并且DRIL1和DRIL2在E2F靶基因表达和细胞周期进程中起重要作用。此外，我们的结果提示DRIL2功能是成骨分化所必需的。这些结果为人类肿瘤抑制通路的调控提供了重要的见解。

The pathways regulated by p53 and RB tumor suppressors and TGF-βsignaling play important roles in tumor suppression in human. In this study, we investigated the functional roles of DRIL1 and its closely related DRIL2, family members of ARID(AT-rich interaction domain) DNA-binding proteins, in three major tumor suppressor pathways. We found that DRIL1 cooperates with p53 to activate pro-arrest p21^<WAF1> transcription, and that DRIL1 and DRIL2 play important roles in E2F-target gene expression and cell cycle progression. In addition, our results suggest that DRIL2 function is required for osteogenic differentiation. These results provide important insights in the regulation of human tumor suppressor pathways.