Functional Roles of Nuclear Matrix Binding Factors in Major Tumor Suppressor Pathways in Human

核基质结合因子在人类主要肿瘤抑制途径中的功能作用

• 批准号: 21390502
• 负责人: IKEDA Masaaki
• 金额: $ 11.65万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390502/
• 关键词: 実験腫瘍学; 癌抑制遺伝子; p53; RB; 分子生物学; 細胞周期; アポトーシス; 核内高次機能; 核マトリクス結合因子

The pathways regulated by p53 and RB tumor suppressors and TGF-βsignaling play important roles in tumor suppression in human. In this study, we investigated the functional roles of DRIL1 and its closely related DRIL2, family members of ARID(AT-rich interaction domain) DNA-binding proteins, in three major tumor suppressor pathways. We found that DRIL1 cooperates with p53 to activate pro-arrest p21^<WAF1> transcription, and that DRIL1 and DRIL2 play important roles in E2F-target gene expression and cell cycle progression. In addition, our results suggest that DRIL2 function is required for osteogenic differentiation. These results provide important insights in the regulation of human tumor suppressor pathways.

由p53和Rb肿瘤助推器调节的途径和TGF-β信号在人类肿瘤抑制中起重要作用。在这项研究中，我们研究了DRIL1及其密切相关的DRIL2的功能作用，即在三种主要的肿瘤抑制途径中的ARID（富含相互作用域）DNA结合蛋白的家族成员。我们发现DRIL1与p53合作以激活Pro-Trast P21^<WAF1>转录，并且Dril1和Dril2在E2F靶标基因表达和细胞周期进程中起着重要作用。此外，我们的结果表明dril2功能是成骨分化所必需的。这些结果为调节人类肿瘤抑制途径提供了重要的见解。

项目成果

In vitro antioxidant and antiproliferative activities of three Malaysian sea cucumber species

• 发表时间: 2009
• 期刊: Electronics
• 影响因子: 2.9
• 作者: Osama Y. Althunibat;R. Hashim;M. Bakhtiar;J. Daud;Masayuki Ikeda;Z. Ibrahim

Cyclin E expression in early neural stem cells during adult hippocampal neurogenesis

成年海马神经发生过程中早期神经干细胞中细胞周期蛋白 E 的表达

• 发表时间: 2010
• 作者: Yayoi Ikeda;Masahiko Takiguchi;Masa-Aki Ikeda
• 通讯作者: Masa-Aki Ikeda

Expression of cyclin E in the cerebral and cerebellar cortices

细胞周期蛋白 E 在大脑和小脑皮质中的表达

• 发表时间: 2009
• 作者: Ikeda Y;Matsunaga Y;Ikeda M-A
• 通讯作者: Ikeda M-A

生殖腺特異的SF-1ノックアウトマウスの精巣におけるセルトリ細胞の分化異常

性腺特异性SF-1敲除小鼠睾丸支持细胞的异常分化

• 发表时间: 2012
• 作者: 池田やよい;加藤朋子
• 通讯作者: 加藤朋子

Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential

• DOI: 10.1073/pnas.1011054107
• 发表时间: 2010-11
• 期刊: Proceedings of the National Academy of Sciences
• 作者: Yoshinori Ohno;S. Yasunaga;M. Ohtsubo;Sayaka Mori;M. Tsumura;S. Okada;T. Ohta;K. Ohtani;Masao Kobayashi;Y. Takihara