Development of a novel healing system for bone disease using a synergetic effect of magnetic fields and bone-regulating hormone
Development of a novel healing system for bone disease using a synergetic effect of magnetic fields and bone-regulating hormone
批准号:
21500404
负责人:
SUZUKI Nobuo
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
为了开发一种利用磁场治疗骨病的新系统,我们利用体外实验系统研究了极低频(ELF)磁场(60Hz)对金鱼鳞片成骨细胞和破骨细胞的影响。在体外实验中,金鱼鳞片的成骨细胞和破骨细胞对极低频磁场反应敏感。结果与大鼠颅骨成骨细胞和破骨细胞的结果一致。此外,磁场和骨骼调节激素褪黑激素的协同作用也得到了证实。因此,我们成功地创造了一种利用磁场治疗骨病的新系统。
英文摘要
To develop a novel healing system for bone disease using magnetic fields, we examined the effects of extremely low-frequency(ELF) magnetic fields(60Hz) on osteoblasts and osteoclasts of goldfish scales using in vitro assay systems. The osteoblasts and osteoclasts in goldfish scales responded sensitively to the ELF magnetic fields in an in vitro experiment. The results agreed with those of rat calvarial osteoblasts and osteoclasts. In addition, the synergetic effect of magnetic fields and a bone-regulating hormone, melatonin, was confirmed. Thus, we succeeded in creating a novel healing system for bone disease by magnetic fields.
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骨とメラトニン
骨骼和褪黑激素
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[古川育代, 宅見央子, 藤嶋昇, 白石浩荘, 米谷俊, 内貴猛, 林紘三郎, 服部淳彦,池亀美華,矢野幸子,鈴木信雄]
通讯作者:
服部淳彦,池亀美華,矢野幸子,鈴木信雄
物理的刺激に対するメダカのウロコの骨芽及び破骨細胞の応答
青鳉鳞片中的成骨细胞和破骨细胞对物理刺激的反应
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[矢野幸子, 大森克徳, 佐藤雄亮, 北村敬一郎, 丸山雄介, 中野真樹, 服部淳彦, 池亀美華, 鈴木信雄]
通讯作者:
鈴木信雄
魚類の再生ウロコの骨代謝に及ぼす機械的刺激の影響: in vivoおよびin vitroのアッセイによる解析
机械刺激对再生鱼鳞骨代谢的影响:使用体内和体外测定进行分析。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ken-ichi Kimura, Akira Urushizaki, Chiaki Sato, Rie Matsuda, Daisuke Yamamoto, 針山孝彦・津田基之, 池亀美華,服部淳彦,北村敬一郎,田畑純,矢野幸子,山本敏男,鈴木信雄, 針山孝彦, 本川達雄, 木村賢一, 関あずさ,鈴木信雄,染井正〓,矢野幸子,服部淳彦, 針山孝彦(日本化学会 編), 木村賢一, 吉村和也・本川達雄, 針山孝彦, 佐藤雄亮,根本鉄,鈴木信雄,矢野幸子,服部淳彦,北村敬一郎]
通讯作者:
佐藤雄亮,根本鉄,鈴木信雄,矢野幸子,服部淳彦,北村敬一郎
Effects of inorganic mercury on osteoclasts and osteoblasts of the goldfish scales in vitro.
无机汞对体外金鱼鳞片破骨细胞和成骨细胞的影响。
DOI:
--
发表时间:
2011
期刊:
J.Fac.Agr., Kyushu Univ.
影响因子:
--
作者:
[Suzuhi, N.]
通讯作者:
N.
DOI:
10.1016/j.bone.2011.02.004
发表时间:
2011-05-01
期刊:
BONE
影响因子:
4.1
作者:
[Suzuki, Nobuo, Danks, Janine A., Martin, T. John]
通讯作者:
Martin, T. John
共 44 条
Analysis of bone metabolism in micro- and hypergravity using a novel hard-tissue model
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批准号:24620004
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.49万
-
财政年份:2012
-
负责人:SUZUKI Nobuo
-
依托单位:
The role of chaperones and micro RNA on regulation of radiation-induced mutation in human physiological functions.
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批准号:20510048
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2008
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负责人:SUZUKI Nobuo
-
依托单位:
The study of modulating effects on X-ray induced cell mutability by chaperons and autophagy
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批准号:18510041
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.64万
-
财政年份:2006
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负责人:SUZUKI Nobuo
-
依托单位:
Development of ultrasound therapy for bone and dental diseases using novel hard-tissue models
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批准号:18500375
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
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负责人:SUZUKI Nobuo
-
依托单位:
The study of modulating effects on X-ray induced cell mutability by chaperons and SUMO.
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批准号:16510032
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2004
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负责人:SUZUKI Nobuo
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依托单位:
The relationship between molecular mechanisms of serum factors and bystander effects modulating cell mutability.
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批准号:14580561
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2002
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负责人:SUZUKI Nobuo
-
依托单位:
Molecular physiological mechanisms which modulate radiation-induced mutagenicity in human.
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批准号:12680539
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2000
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负责人:SUZUKI Nobuo
-
依托单位:
Studies on cytokines and proteases which regulate UV-induced mutation in human cells
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批准号:09680516
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:1997
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负责人:SUZUKI Nobuo
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依托单位:
Purification of protease induced by ultraviolet ray in human cells.
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批准号:07680571
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:SUZUKI Nobuo
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依托单位:
The exploitation of visual-audio Leaching materials of eachi course of study on natural environmental learning.
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批准号:05451149
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.35万
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财政年份:1993
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负责人:SUZUKI Nobuo
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依托单位:
Study on UV-induced protease of hunam cells
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批准号:03680179
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1991
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负责人:SUZUKI Nobuo
-
依托单位:
Study on selective separation and determination of trace metal species in biological and geological samples.
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批准号:62430008
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$14.66万
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财政年份:1987
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负责人:SUZUKI Nobuo
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依托单位:
Analysis of human cells with super-sensitivity to mutagenicity
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批准号:61580176
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.6万
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财政年份:1986
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负责人:SUZUKI Nobuo
-
依托单位:
海外基金