The role of chaperones and micro RNA on regulation of radiation-induced mutation in human physiological functions.
The role of chaperones and micro RNA on regulation of radiation-induced mutation in human physiological functions.
批准号:
20510048
负责人:
SUZUKI Nobuo
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The following two points were mainly identified in mechanisms which regulate mutability in human. (1) When the HSP27 and annexin II complex is involved in DNA repair pathways for UVC-caused DNA damages, HSP27 may protect annexin II from the breakdown after UVC irradiation. Annexin II is released from cells and the released one may be involved in cellular UVC-resistance via signal transduction pathways. (2) The miRNAs, which may be involved in cell growth and mutation, were found.
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Combinatory use of adenoviruses-mediated cell death,chemotherapeutuc agents and a novel interferon produced enhanced cytotoxicity to targeted tumor cells.
腺病毒介导的细胞死亡、化疗药物和新型干扰素的联合使用增强了对靶向肿瘤细胞的细胞毒性。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Tagawa, et al.]
通讯作者:
et al.
Xylomexicanins A and B, New △14,15-Mexicanolides from Seeds of the Chinese Mangrove Xylocarpus granatum
中国红树木果种子中新的△14,15-墨西哥内酯A和B、新△14,15-墨西哥内酯
DOI:
--
发表时间:
2009
期刊:
Z.Naturforsch 64c
影响因子:
--
作者:
[Li-Ru Shen, Mei Dong, Dong Guo, Bao-Wei Yin, Man-Li Zhang, Qing-Wen Shi, Chang-Hong Huo, Hiromasa Kiyotad, Shuzuki N., Bin Cong.]
通讯作者:
Bin Cong.
The roles of HSP27 and annexin II in resistance to UVC-induced cell death ; comparative studies between the human UVC-sensitive and -resistant cell lines, RSa and AP^r-1.
HSP27 和膜联蛋白 II 在抵抗 UVC 诱导的细胞死亡中的作用;
DOI:
--
发表时间:
期刊:
Biosci. Biotec. Biochem. (in press)
影响因子:
--
作者:
[Jin, Y-H., Kita, K., Sun, Z., Tong, X-B., Nie, H., Suzuki, N.]
通讯作者:
N.
DOI:
10.2741/2867
发表时间:
2008-01-01
期刊:
FRONTIERS IN BIOSCIENCE-LANDMARK
影响因子:
3.1
作者:
[Tagawa, Masatoshi, Kawamura, Kiyoko, Ochiai, Tekenori]
通讯作者:
Ochiai, Tekenori
細胞外に添加されたHSPB-Aによるコケイン症候群患者由来細胞の紫外線致死抵抗化
细胞外添加HSPB-A对科凯恩综合征患者来源细胞的紫外线致死抵抗力
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[喜多和子, 杉田克生, 陳仕萍, 佐藤哲生, 郭文智, 鈴木敏和, 菅谷茂, 鈴木信夫]
通讯作者:
鈴木信夫
共 48 条
Analysis of bone metabolism in micro- and hypergravity using a novel hard-tissue model
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批准号:24620004
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2012
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负责人:SUZUKI Nobuo
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依托单位:
Development of a novel healing system for bone disease using a synergetic effect of magnetic fields and bone-regulating hormone
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批准号:21500404
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2009
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负责人:SUZUKI Nobuo
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依托单位:
The study of modulating effects on X-ray induced cell mutability by chaperons and autophagy
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批准号:18510041
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.64万
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财政年份:2006
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负责人:SUZUKI Nobuo
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依托单位:
Development of ultrasound therapy for bone and dental diseases using novel hard-tissue models
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批准号:18500375
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
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负责人:SUZUKI Nobuo
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依托单位:
The study of modulating effects on X-ray induced cell mutability by chaperons and SUMO.
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批准号:16510032
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2004
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负责人:SUZUKI Nobuo
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依托单位:
The relationship between molecular mechanisms of serum factors and bystander effects modulating cell mutability.
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批准号:14580561
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2002
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负责人:SUZUKI Nobuo
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依托单位:
Molecular physiological mechanisms which modulate radiation-induced mutagenicity in human.
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批准号:12680539
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2000
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负责人:SUZUKI Nobuo
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依托单位:
Studies on cytokines and proteases which regulate UV-induced mutation in human cells
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批准号:09680516
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:1997
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负责人:SUZUKI Nobuo
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依托单位:
Purification of protease induced by ultraviolet ray in human cells.
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批准号:07680571
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:SUZUKI Nobuo
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依托单位:
The exploitation of visual-audio Leaching materials of eachi course of study on natural environmental learning.
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批准号:05451149
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.35万
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财政年份:1993
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负责人:SUZUKI Nobuo
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依托单位:
Study on UV-induced protease of hunam cells
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批准号:03680179
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1991
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负责人:SUZUKI Nobuo
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依托单位:
Study on selective separation and determination of trace metal species in biological and geological samples.
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批准号:62430008
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$14.66万
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财政年份:1987
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负责人:SUZUKI Nobuo
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依托单位:
Analysis of human cells with super-sensitivity to mutagenicity
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批准号:61580176
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.6万
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财政年份:1986
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负责人:SUZUKI Nobuo
-
依托单位:
海外基金