Development of Highly Selective Addition Reaction with Metal Ate Salt Catalysts

有机金属试剂对羰基化合物的加成反应是有机化学中最重要的反应之一。在这项研究中，我们开发的活化，不仅反应性较低的酮，但也有机金属试剂使用高活性的金属酸盐催化剂。基于碳-金属键的活化和随后的碳-碳键形成反应，我们开发了高效、实用的叔醇合成方法。此外，建立了手性锌（II）酸盐催化剂存在下的催化不对称叔醇的合成。

Addition of organometallic reagents to carbonyl compounds is one of the most important reactions in organic chemistry. In this study, we developed the activation of not only less reactive ketones but also organometallic reagents using highly active metal ate salt catalysts. Based on the activation of carbon-metal bond and the subsequent carbon-carbon bond forming reactions, we developed the highly efficient, practical tertiary alchol synthesis. Moreover, catalytic asymmetric tertiary alchol synthesis was established in the presence of chiral Zn(II)-ate catalysts.