Design of Conformationally Flexible Tailor-Made Catalysts toward Higher-Ordered-Selective Reactions Based on Single/Supra-molecular Chemistry

为了在世纪发展高效的绿色可持续化学，我们利用小分子酸碱之间的各种缔合作用设计了高活性催化剂。 开发新型“定制催化剂”的关键是实现反应的更高有序的底物、区域、化学和立体选择性，这是介于单分子化学和超分子化学之间的特殊设计和技术。 在此背景下，我们开发了构象灵活的手性/非手性酸碱组合催化剂，这些催化剂在催化不对称缩醛胺合成、叔醇合成、aza-Friedel-Crafts反应、Mannich型反应、氰基硅烷化、1，4-氢膦化/1，2-氢膦化、Diels-Alder反应、酯交换反应等方面具有很高的效率。

To develop an extremely efficient green sustainable chemistry in the 21st century, we designed the highly active catalysts with the use of a variety of associative interactions between acids and bases of small molecules. The key to developing the novel ‘tailor-made catalysts’ toward the higher-ordered substrate-, regio-, chemical-, stereo-selectivities of the reactions is special designs and techniques between single-molecule chemistry and supramolecular chemistry. In this context, we developed conformationally flexible chiral/achiral acid-base combined catalysts, which were highly effective for, such as, catalytic asymmetric aminal synthesis, tertiary alcohol synthesis, aza-Friedel-Crafts reaction, Mannich-type reaction, cyanosilylation, 1,4-hydrophosphinylation/1,2-hydrophosphonylation, Diels-Alder reaction, transesterification, etc.