Analysis of bacteriophage Qβ genome evolution in an experimental coevolution system

进化如何影响寄生虫基因组序列的变化？为了阐明协同进化的影响，我们构建了由大肠杆菌和裂解噬菌体Qβ(Qβ噬菌体)组成的实验性协同进化系统和唯一寄生虫进化系统。我们在这两个系统中传代了大约170代Qβ噬菌体。比较两种进化系统中Qβ噬菌体基因组序列的顺序变化(随时间变化)，发现共同进化系统的固定率约高3.4%。

How does evolution affect changes in parasite genome sequences? To elucidate the effects of coevolution, we constructed an experimental coevolution system and sole parasite evolution system consisting of Escherichia coli and the lytic RNA bacteriophage Qβ (Qβ phage). We passaged Qβ phage in both systems for approximately 170 phage generations. Comparison of sequential (time-dependent) changes in the Qβ phage genome sequence in both evolution systems revealed that the coevolution system showed about 3.4-fold higher fixation rate.