Epigenetic analysis in the individual level by mice engineered using artificial chromosome vectors

最近，表观遗传学与人类发育和疾病之间的相关性已经被揭示。重要的是利用稳定保持遗传修饰的模型动物在个体水平上进一步验证这些发现。在本研究中，我们成功地开发了新的基础技术，以产生稳定维持的人工染色体载体的模型鼠，以监测个体水平的表观遗传学变异。这些小鼠模型将有助于分析各种生物现象引起的表观遗传学和生理基因表达的变化。

Recently, the relevance between epigenetics and human development and diseases has been revealed. It is important to utilize model animals maintained stably the genetical modification to be verified further these findings in individual level. In this study, we succeeded the development of the novel basic technology to generate model mice maintained stably artificial chromosome vectors to monitor the variations of epigenetics in individual level. These mice models will be useful for analyses of changes of the epigenetics and physiological gene expression arising from various biological phenomena.