Design of proline analogues based on hybrid methods and their application

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The de novo design of peptides that fold into well-defined secondary structures is crucially important in a wide variety of fields such as organic chemistry, and biological and material sciences. Approaches to controlling the conformations of peptides have been studied, and as templates for stabilizing the secondary structures of peptides, α, α-disubstituted α-amino acids have been widely used. In this study, we demonstrated the synthesis of proline analogues and stabilized short helical peptides, and their application to the enantioselective epoxidation of (E)-chalcone.