Development of novel catalytic reactions of alkyne derivatives for the construction of heterocycles

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We developed efficient synthetic methods of heterocyclic compounds by means of consecutive bond formation approaches based on each of the following reactions : 1) syntheses of highly substituted pyrroles and furans via Au-catalyzed Claisen rearrangement reactions, 2) syntheses of oxazoles and furans concomitantly with incorporation of allyl gropes or oxygen functional gropes via Pd-catalyzed cyclization-allylation sequences or metal-free oxidative cyclization reactions, and 3) syntheses of dihydroquinolines and iminoquinolinones via hetero en-yne metatheses.