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Development of tissue specific siRNA expression system to vascular endothelial cells in cancer

Development of tissue specific siRNA expression system to vascular endothelial cells in cancer
开发针对癌症血管内皮细胞的组织特异性 siRNA 表达系统
批准号:
21790161
负责人:
KOIZUMI Naoya
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
We tried development of novel tissue specific siRNA expression system for cancer gene therapy by VSV-G lentivirus vector. Therefore, we substituted sequence of CCR5-siRNA in endogenous microRNA for driving by tissue specific promoter (RNA polymerase type II). As a result, the siRNA expression system had not worked by RNA polymerase type II promoter. We need further study for the development of tissue specific siRNA expression system.
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DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [小泉直也, Suree Tom, 清水佐紀, 渡辺善照, 安東星]
通讯作者: 安東星
DOI: 10.1182/blood-2009-04-215855
发表时间: 2010-02-25
期刊: BLOOD
影响因子: 20.3
作者: [Shimizu, Saki, Hong, Patrick, An, Dong Sung]
通讯作者: An, Dong Sung
development of a therapeutic carrier protein for gene therapy
  • 批准号:
    17K08464
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.0万
  • 财政年份:
    2017
  • 负责人:
    KOIZUMI Naoya
  • 依托单位:
The development of protein delivery system through the cell membrane
  • 批准号:
    25670082
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.41万
  • 财政年份:
    2013
  • 负责人:
    KOIZUMI Naoya
  • 依托单位:
Basic Study of orally-delivered vaccine development using a new innate immunity inducer
  • 批准号:
    23659086
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.41万
  • 财政年份:
    2011
  • 负责人:
    KOIZUMI Naoya
  • 依托单位:
Development of fiber modified adenovirus vector
  • 批准号:
    19790135
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.36万
  • 财政年份:
    2007
  • 负责人:
    KOIZUMI Naoya
  • 依托单位:
海外基金