Regulation of insulin secretion by sphingolipids

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Sphingomyelin synthase 1 (SMS1) catalyzes the conversion of ceramide to sphingomyelin, and has a central role in controlling sphingolipid homeostasis in the cell. In this study, we analyzed the pathogenesis of SMS1 null mice, which exhibit insulin secretion deficiency. As results, we found that disturbance of sphingolipid homeostasis and increased oxidative stress accompanied with mitochondrial dysfunction underlies insulin secretion deficiency observed in pancreatic beta-cells of SMS1 null mice. Furthermore, anti-oxidant treatment recovered insulin secretion deficiency in SMS1 null mice.