Analysis for the mechanism of inducing the autoimmune-like diseases in the Ste20-like kinase Mst1 deficient mice.

点击翻译按钮获取中文摘要

Mst1 deficient mice exhibited autoimmune phenotypes such as leukocyte infiltration in multiple tissues as well as the production of autoantibody. Indeed, Mst1 deficiency caused impaired the thymocyte selection in the TCR transgenic models as well as the generation of Treg in the thymus. Observation of thymocyte dynamcis on the thymic slice by 2-photon microscope revealed the defective thymocyte migration in the cortex and medulla. Our observations suggest the novel roles for Mst1 in the regulation of self-tolerance.