Elucidation of roles played by MRTF-A, a rho-dependent transcriptional co-activator, in pathological cardiac remodeling

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In this study, we evaluated roles played by myocardin-related transcription factor-A (MRTF-A), a co-activator of serum response factor (SRF), in pathological cardiac remodeling. Mechanical stress and neurohumoral stimulation onto cardiac myocytes induced nuclear translocation of MRTF-A, a co-activator of serum response factor (SRF) in a Rho and actin dynamics-dependent manner, thereby activating SRF. Our findings define the Rho- and actin dynamics-dependent nuclear translocation of MRTF-A as a novel common signaling mechanism underlying both mechanical stretch- and neurohumoral stimulation-induced cardiac hypertrophy and fetal gene activation during pathological cardiac remodeling.