Elucidation of roles played by MRTF-A, a rho-dependent transcriptional co-activator, in pathological cardiac remodeling

在这项研究中，我们评估了心肌素相关转录因子-a （MRTF-A）在病理性心脏重构中的作用，MRTF-A是血清反应因子（SRF）的共同激活因子。对心肌细胞的机械应力和神经体液刺激诱导MRTF-A的核易位，MRTF-A是血清反应因子（SRF）的共同激活剂，以Rho和肌动蛋白动力学依赖的方式激活SRF。我们的研究结果将MRTF-A依赖于Rho和肌动蛋白动力学的核易位定义为病理性心脏重构过程中机械拉伸和神经体液刺激诱导的心脏肥厚和胎儿基因激活的一种新的共同信号机制。

In this study, we evaluated roles played by myocardin-related transcription factor-A (MRTF-A), a co-activator of serum response factor (SRF), in pathological cardiac remodeling. Mechanical stress and neurohumoral stimulation onto cardiac myocytes induced nuclear translocation of MRTF-A, a co-activator of serum response factor (SRF) in a Rho and actin dynamics-dependent manner, thereby activating SRF. Our findings define the Rho- and actin dynamics-dependent nuclear translocation of MRTF-A as a novel common signaling mechanism underlying both mechanical stretch- and neurohumoral stimulation-induced cardiac hypertrophy and fetal gene activation during pathological cardiac remodeling.