Elucidation of roles played by MRTF-A, a rho-dependent transcriptional co-activator, in pathological cardiac remodeling

阐明 MRTF-A（一种 rho 依赖性转录共激活因子）在病理性心脏重塑中的作用

• 批准号: 21790719
• 负责人: USAMI Satoru
• 金额: $ 2.75万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790719/
• 关键词: 心筋リモデリング; 遺伝子転写調節; アンジオテンシンII

In this study, we evaluated roles played by myocardin-related transcription factor-A (MRTF-A), a co-activator of serum response factor (SRF), in pathological cardiac remodeling. Mechanical stress and neurohumoral stimulation onto cardiac myocytes induced nuclear translocation of MRTF-A, a co-activator of serum response factor (SRF) in a Rho and actin dynamics-dependent manner, thereby activating SRF. Our findings define the Rho- and actin dynamics-dependent nuclear translocation of MRTF-A as a novel common signaling mechanism underlying both mechanical stretch- and neurohumoral stimulation-induced cardiac hypertrophy and fetal gene activation during pathological cardiac remodeling.

在这项研究中，我们评估了心肌素相关转录因子-a （MRTF-A）在病理性心脏重构中的作用，MRTF-A是血清反应因子（SRF）的共同激活因子。对心肌细胞的机械应力和神经体液刺激诱导MRTF-A的核易位，MRTF-A是血清反应因子（SRF）的共同激活剂，以Rho和肌动蛋白动力学依赖的方式激活SRF。我们的研究结果将MRTF-A依赖于Rho和肌动蛋白动力学的核易位定义为病理性心脏重构过程中机械拉伸和神经体液刺激诱导的心脏肥厚和胎儿基因激活的一种新的共同信号机制。

项目成果

Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes

• DOI: 10.1016/j.yjmcc.2011.01.017
• 发表时间: 2011-06-01
• 期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
• 影响因子: 5
• 作者: Hata, Leo;Murakami, Masao;Nakao, Kazuwa
• 通讯作者: Nakao, Kazuwa

The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2

• DOI: 10.1093/cvr/cvp171
• 发表时间: 2009-09-01
• 期刊: CARDIOVASCULAR RESEARCH
• 影响因子: 10.8
• 作者: Kuratomi, Shinobu;Ohmori, Yoko;Takano, Makoto
• 通讯作者: Takano, Makoto

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Prognostic value of myocardial perfusion SPECT images in combination with the maximal heart rate at exercise testing in Japanese patients with suspected ischemic heart disease : a sub-analysis of J-ACCESS.

心肌灌注 SPECT 图像与运动测试时最大心率相结合对日本疑似缺血性心脏病患者的预后价值：J-ACCESS 的子分析。

• 发表时间: 2009
• 期刊: Annals of Nuclear Medicine 23
• 作者: Ueshima K;Usami S;他6名
• 通讯作者: 他6名

CT dinucleotide repeat polymorphism in the promoter region of Guanylyl Cyclase-A gene is associated with essential hypertension in the Japanese.

鸟苷酸环化酶-A基因启动子区的CT二核苷酸重复多态性与日本人的原发性高血压有关。

• 发表时间: 2010
• 作者: Satoru Usami;et al.
• 通讯作者: et al.