Structural studies on IL-18 ligand receptor complex for designing new drugs of allergy and autoimmune diseases
Structural studies on IL-18 ligand receptor complex for designing new drugs of allergy and autoimmune diseases
批准号:
21790979
负责人:
KIMURA Takeshi
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Inter leukin-18(IL-18), found as interferon-γinducing factor, plays a critical role in innate and acquired immune response against microbes. IL-18 would also contribute to the pathogenesis of inflammatory diseases. To elucidate the pathogenesis and structure of IL-18 I igand-receptor complex, we have expressed recombinant IL-18Rαand IL-18Rβwith baculo-Insect cell systems and crystallized it as IL-18/IL18Rα/IL-18Rβheterotr imer ic complex and obtained X-ray diffraction data from the crystal.
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会议论文
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昆虫细胞培养系统中可溶性 ST2 抑制 IL-33 活性的研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[木村豪, 大西秀典, 松井永子, 加藤善一郎, 近藤直実]
通讯作者:
近藤直実
Structural basis for receptor recognition of interleukin 18
白细胞介素18受体识别的结构基础
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Naotaka Tutsumi, Takeshi Kimura, Hidenori Ohnishi, Zen-ichiro Kato, Hidehito Tochio, nomi Kondo, Masahiro Shirakawa]
通讯作者:
Masahiro Shirakawa
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依托单位:
海外基金