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Structural studies on IL-18 ligand receptor complex for designing new drugs of allergy and autoimmune diseases

Structural studies on IL-18 ligand receptor complex for designing new drugs of allergy and autoimmune diseases
IL-18配体受体复合物的结构研究用于设计过敏和自身免疫性疾病新药
批准号:
21790979
负责人:
KIMURA Takeshi
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Inter leukin-18(IL-18), found as interferon-γinducing factor, plays a critical role in innate and acquired immune response against microbes. IL-18 would also contribute to the pathogenesis of inflammatory diseases. To elucidate the pathogenesis and structure of IL-18 I igand-receptor complex, we have expressed recombinant IL-18Rαand IL-18Rβwith baculo-Insect cell systems and crystallized it as IL-18/IL18Rα/IL-18Rβheterotr imer ic complex and obtained X-ray diffraction data from the crystal.
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会议论文
昆虫細胞培養系由来可溶性ST2によるIL-33活性阻害の検討
昆虫细胞培养系统中可溶性 ST2 抑制 IL-33 活性的研究
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [木村豪, 大西秀典, 松井永子, 加藤善一郎, 近藤直実]
通讯作者: 近藤直実
Structural basis for receptor recognition of interleukin 18
白细胞介素18受体识别的结构基础
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Naotaka Tutsumi, Takeshi Kimura, Hidenori Ohnishi, Zen-ichiro Kato, Hidehito Tochio, nomi Kondo, Masahiro Shirakawa]
通讯作者: Masahiro Shirakawa
Elucidation of the mechanism of neoatherosclerosis
  • 批准号:
    25293182
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.9万
  • 财政年份:
    2013
  • 负责人:
    KIMURA Takeshi
  • 依托单位:
Engaged Research in Constructing Cultural Value for balancing economic development and environmental conservation in light of religious teaching
  • 批准号:
    25580013
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $1.91万
  • 财政年份:
    2013
  • 负责人:
    KIMURA Takeshi
  • 依托单位:
New approach to analyze inherited arrhythmias using human iPS cells
  • 批准号:
    24659387
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.41万
  • 财政年份:
    2012
  • 负责人:
    KIMURA Takeshi
  • 依托单位:
Analyses of the long-term outcomes and prognostic factors of Japanese patients undergoing first coronary revascularization.
  • 批准号:
    18590771
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.53万
  • 财政年份:
    2006
  • 负责人:
    KIMURA Takeshi
  • 依托单位:
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