Therapeutic Effect of Hydrogen on Monocrotaline-induced Pulmonary Hypertension in Rat.

氢气对野百合碱诱导的大鼠肺动脉高压的治疗作用。

• 批准号: 21790981
• 负责人: KATO Taichi
• 金额: $ 2万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790981/
• 关键词: 肺高血圧; 酸化ストレス; 炎症

The effect of hydrogen on monocrotaline-induced pulmonary hypertension in rat was evaluated. Hydrogen improved systolic right ventricular pressure and musucularization of pulmonary vasculature. Furthermore, in monocrotaline-induced pulmonary hypertension rat, the numbers of perivascular macrophages, fibroblasts, 8OhdG-positive cells and Ki-67-positive cells were increased, which were suppressed by hydrogen. These results suggest hydrogen ameliorates monocrotaline-induced pulmonary hypertension in rat via anti-inflammatory, anti-oxidative stress and anti-proliferative effect.

评估了氢气对野百合碱诱导的大鼠肺动脉高压的作用。氢气改善了右心室收缩压和肺血管系统的肌肉化。此外，在野百合碱诱导的肺动脉高压大鼠中，血管周围巨噬细胞、成纤维细胞、8OhdG阳性细胞和Ki-67阳性细胞的数量增加，而氢气抑制了这些细胞的数量。这些结果表明氢气通过抗炎、抗氧化应激和抗增殖作用改善野百合碱诱导的大鼠肺动脉高压。

项目成果

Contribution of bone marrow stem cells to the pathogenesis of pulmonary hypertension and pharmacological modulation of bone marrow-derived cells as a therapeutic target

骨髓干细胞对肺动脉高压发病机制的贡献以及骨髓来源细胞作为治疗靶点的药理学调节

• 发表时间: 2010
• 作者: Wang S;et al.(他7名;4番目);加藤太一
• 通讯作者: 加藤太一

マウス肺高血圧発症における骨髄由来幹細胞の役割とボセンタンによる制御-肺高血圧に対する内科的再生医療の可能性-

骨髓干细胞在小鼠肺动脉高压发生中的作用及波生坦的控制 - 医学再生医学治疗肺动脉高压的可能性 -

• 发表时间: 2009
• 作者: 加藤太一;三谷義英;澤田博文;池山夕起子;出口隆生;桝屋正浩;宮田恵里;丸山淳子;丸山一男;新保秀人;駒田美弘
• 通讯作者: 駒田美弘

Bosentan promotes incorporation of bone marrow-derived endothelial cells but inhibits infiltration of macrophages into pulmonary vascular lesions in mice exposed to chronic hypoxia: A novel concept of bosentan therapy in pulmonary hypertension

波生坦促进骨髓源性内皮细胞的掺入，但抑制巨噬细胞浸润慢性缺氧小鼠的肺血管病变：波生坦治疗肺动脉高压的新概念

• 发表时间: 2009
• 作者: Kato T;Sawada H;Maruyama J;Ikeyama Y;Ohashi H;Masuya M;Miyata E;Nakamura S;Shimpo H;Maruyama K;Komada Y;Mitani Y.
• 通讯作者: Mitani Y.

Contribution of bone marrow stem cells to the pathogenesis of pulmonary hypertension and pharmacological modulation of bone marrow-derived cells as a therapeutic target.

骨髓干细胞对肺动脉高压发病机制的贡献以及骨髓来源细胞作为治疗靶点的药理调节。

• 发表时间: 2010
• 作者: Kato T;Sawada H;Maruyama J;Masuya M;Miyata E;Nakamura S;Ikeyama Y;Shimpo H;Maruyama K;Komada Y;Mitani Y.
• 通讯作者: Mitani Y.

Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma.

两例先天性中胚层肾瘤羊水中醛固酮水平升高。

• 发表时间: 2010
• 期刊: Ultrasound Obstet Gynecol 36
• 作者: Kotani T;Sumigama S;Hayakawa H;Mano Y;Tsuda H;Sugiyama C;Kawachi F;Hironaka M;Kato T;Kaneko K;Hayakawa M;Kikkawa F.
• 通讯作者: Kikkawa F.