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Correlation between ERG and morphometric parameters of optic nerve head and nerve fiber layer

ERG与视神经乳头和神经纤维层形态参数的相关性

基本信息

批准号：
21791707
负责人：
MIYAMOTO Hiroyuki
金额：
$ 2.58万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2010
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791707/
关键词：
緑内障視機能網膜電図視神経網膜機能動物モデル眼科

项目摘要

Purpose : To determine the relationship between the photopic negative response (PhNR) of the focal electoretinogram (ERG) and the structural parameters of the inner retina and optic nerve head in glaucoma. Methods : Sixty-one eyes of 61 patients with open angle glaucoma (OAG), 13 eyes of 13 patients who were classified as glaucoma suspects, and 30 eyes of 30 normal subjects were studied. The focal ERGs were elicited by a 15° circular white stimulus on a white background centered on the fovea. The focal ERGs were also elicited by half of an annulus placed above or below the macula. The diameter of the inner border of the annulus was 15° and that of the outer border was 30°. The structure of the optic nerve head and retinal nerve fiber layer thickness (RNFLT) were evaluated by scanning laser ophthalmocopy and laser scanning polarimetry, respectively. Results : The amplitudes of the focal PhNRs and the ratio of the focal PhNR/b-wave amplitude were linearly correlated with the corresponding RNFLT in the superior/temporal and inferior/temporal regions (r=0.43 to 0.47 ; P<0.0001) but not in the temporal region. The focal PhNR amplitude and focal PhNR/b-wave amplitude ratio were also linearly and significantly correlated with the corresponding rim areas and cup/disc area ratio (r=0.38 to 0.50, P<0.0001). Conclusions : These results strongly suggest that the anatomical losses of retinal neurons in local areas of the retina or optic nerve head are a cause of the reduction in the amplitude of the focal PhNR in OAG..

目的：目的探讨青光眼局灶视网膜电图（ERG）明视负反应（PhNR）与视网膜内层及视乳头结构参数的关系。研究方法：对61例61眼开角型青光眼（OAG）、13例13眼可疑青光眼和30例30眼正常人进行了研究。在以中央凹为中心的白色背景上，通过15°圆形白色刺激诱发局灶性ERG。局灶性视网膜电图也引起了一半的环上方或下方的黄斑。瓣环内缘直径15°，外缘直径30°。分别用激光扫描检眼镜和激光扫描偏振仪测量视乳头结构和视网膜神经纤维层厚度（RNFLT）。结果如下：在上级/颞区和下级/颞区，局灶性PhNR的振幅和局灶性PhNR/b波振幅的比值与相应的RNFLT呈线性相关（r=0.43 ~ 0.47 ; P<0.0001），但在颞区不相关。局灶性PhNR振幅和局灶性PhNR/b波振幅比值与相应的边缘面积和杯盘面积比值呈显著线性相关（r=0.38 ~ 0.50，P<0.0001）。结论：这些结果强烈表明，视网膜或视神经乳头局部区域中视网膜神经元的解剖学损失是OAG中局灶性PhNR振幅降低的原因。