Identification of drug-metabolizing enzymes associated with human tongue carcinogenesis using genetic polymorphisms

利用遗传多态性鉴定与人类舌癌发生相关的药物代谢酶

• 批准号: 21791827
• 负责人: HIRANO Masato
• 金额: $ 2.75万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791827/
• 关键词: 舌癌; 薬物代謝酵素; 遺伝子多型

We have recently reported that a genetic polymorphism of the type II detoxifying enzyme NQO1 may be a major determinant of the susceptibility of rats to oral squamous-cell carcinoma(OSCC) induced by 4-nitroquinoline 1-oxide(4NQO). To test whether this is also the case in human OSCC, polymorphisms of NQO1, CYP1A1 and GSTP1 were examined in a population-based case-control study. In NQO1 and CYP1A1, the homozygous-variant type was much less common among the subjects in the control group than it was among the OSCC cases. Alternatively, GSTP1 have not yet been completely characterised.

我们最近报道了II型解毒酶NQO1的遗传多态性可能是大鼠对4-硝基喹啉1-氧化物（4NQO）诱导的口腔鳞状细胞癌（OSCC）易感的主要决定因素。为了检验人类OSCC是否也是如此，我们在一项基于人群的病例对照研究中检测了NQO1、CYP1A1和GSTP1的多态性。在NQO1和CYP1A1中，纯合变异型在对照组受试者中的发生率远低于在OSCC病例中的发生率。另外，GSTP1尚未完全表征。

项目成果

FGFR4 polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma

• DOI: 10.3892/or_00000692
• 发表时间: 2010-03-01
• 期刊: ONCOLOGY REPORTS
• 影响因子: 4.2
• 作者: Tanuma, Jun-Ichi;Izumo, Toshiyuki;Kitano, Motoo
• 通讯作者: Kitano, Motoo