Identification of drug-metabolizing enzymes associated with human tongue carcinogenesis using genetic polymorphisms

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We have recently reported that a genetic polymorphism of the type II detoxifying enzyme NQO1 may be a major determinant of the susceptibility of rats to oral squamous-cell carcinoma(OSCC) induced by 4-nitroquinoline 1-oxide(4NQO). To test whether this is also the case in human OSCC, polymorphisms of NQO1, CYP1A1 and GSTP1 were examined in a population-based case-control study. In NQO1 and CYP1A1, the homozygous-variant type was much less common among the subjects in the control group than it was among the OSCC cases. Alternatively, GSTP1 have not yet been completely characterised.