Novel therapeutic strategy for salivary gland carcinoma targeting androgen receptor.

雄激素受体（AR）在前列腺癌中表达，并且激素治疗已被普遍使用。另一方面，据报道，唾液腺癌表达雄激素受体（AR），但很少有人知道它在唾液腺癌中的作用。在这项研究中，我们探讨的可能性，激素治疗涎腺癌。我们检测了雄激素受体在涎腺癌组织和涎腺癌细胞系中的表达。作为免疫组织化学和western筛选的结果，所有涎腺癌组织和涎腺细胞系均为AR阴性。因此，很少有涎腺癌适用于激素治疗。

Androgen receptor(AR) is expressed in prostate carcinoma, and hormonal therapy has been commonly used. On the other hand, it is reported that salivary gland carcinomas express androgen receptor (AR), however little is known regarding its role in the salivary gland carcinoma. In this study, we investigate a possibility of hormonal therapy for salivary gland carcinoma. We evaluated the expression of androgen receptor in a salivary gland carcinoma tissues and salivary gland carcinoma cell lines. As a result of immunohistochemistry and western bolting, all salivary gland carcinoma tissues and salivary gland cell lines were negative for AR. So few salivary gland carcinoma are applicable for hormonal therapy.