The basic research molecular target and immune therapy for oral squamous cell carcinoma with geldanamysin.

开展了格尔德霉素治疗口腔鳞癌的基础研究、分子靶向治疗和免疫治疗。我检测了几种分子，它们参与了口腔鳞状细胞癌的转移和侵袭。并揭示了α-actinin-4、coronin和CRK Ⅱ等分子分别参与口腔鳞癌细胞的转移和侵袭，以及作为分子靶向治疗靶点的可能性。

I performed the basic research molecular target and immune therapy for oral squamous cell carcinoma with geldanamysin. I examined the several molecules, which were involved in the metastasis and invasion in oral squamous cell carcinoma. And, I revealed these molecules such asα-actinin-4, cortactin, and CRKII, were involved in the metastasis and invasion in oral squamous cell lines, respectively, and the possibility of the target of molecular target therapy.