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癌性膵液を用いたサブトラクティブ免疫法による新規単クローン抗体の作製と応用

癌胰液消减免疫新型单克隆抗体的制备及应用

基本信息

批准号：
21659151
负责人：
中島学
金额：
$ 1.79万
依托单位：
Fukuoka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2010
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659151/
关键词：
癌膵液抗体診断免疫学

项目摘要

22年度における本研究は、21年度に樹立したモノクローナル抗体(2P-1-2-1,2P-1-17-1,6P-3-2-4,7p-9-11-6)が認識する抗原の解析を進めると共に、上記免疫方法を用いてヒト肝外胆管がん細胞株特異的モノクローナル抗体2種類(a2-H1-B12,a6-A11-D1)を新規に樹立した。研究成果として、第69回日本癌学会学術総会にて3演題(1)The utility of novel antibodies in pathological diagnosis of pancreatic neoplasm(研究協力者と共同発表)、(2)Approaches to establish new monoclonal antibodies specific for cancerous pancreatic juice by subtractive immunization(3)Establishment of monoclonal antibodies specific for extrahepatic bile duct carcinoma by subtractive immunization、日本薬学会第131年会に2演題の計5演題を発表し、これらの新規モノクローナル抗体の臨床的有用性を示した。また、6P-3-2-4の英文論文(Novel monoclonal antibodies against pancreatic juice from pancreatic cancer patients and their possible application in differential diagnosis)を投稿し受理された(International Journal of Molecular Medicine)。また、a2-H1-B12,a6-A11-D1の英文論文(Novel monoclonal antibodies specific for the extrahepatic bile duct carcinoma cell line (KMBC))も投稿準備が終了した。

In 2002 and 2003, we established two types of antibodies (2P-1-2-1, 2P-1-17-1,6P-3-2-4, 7P-9-11-6) specific to extrahepatic bile duct cell lines using the immune method described above. Research Results: The 69th Academic Conference of Japanese Cancer Society 3 Questions (1)The utility of novel antibodies in pathological diagnosis of pancreatic neoplasia (2)Approaches to establish new monoclonal antibodies specific for cancerous pancreatic juice by subtractive immunization(3)Establishment of monoclonal antibodies specific for extrahepatic bile duct carcinoma by subtractive immunization, The 131st Annual Meeting of the Japan Pharmaceutical Society presented a proposal for the development of a new protocol for the clinical use of antibodies. English paper 6P-3-2-4 (Novel monoclonal antibodies against pancreatic juice from pancreatic cancer patients and their possible application in differential diagnosis) is accepted for submission (International Journal of Molecular Medicine). Paper (Novel monocular antibodies specific for the extrahepatic bile duct carcinoma cell line (KMBC)): a2-H1-B12,a6-A11-D1