Serum DNase I activity can be a useful biomarker for the early diagnosis of transient myocardial ischemia

本研究的目的是评价血清DNase I作为一种新的诊断短暂性心肌缺血的生物标志物的应用：(1)血清DNase I活性水平可以在早期观察到很高的诊断效率，即使在不稳定心绞痛或非ST段抬高的心肌梗死患者中也是如此，这些患者没有表现出常规心脏生物标志物的抬高。因此，血清DNase I活性可作为胸痛后一过性心肌缺血的早期诊断有用的生物标志物。(2)心肌缺血引起的血清DNase I活性的一过性升高可能部分是由于DNase I基因的缺氧反应所致。(3)在DNase I和I样3基因的非同义SNPs中，发现了产生失活/低活性酶的特异性等位基因。这些等位基因可能是自身免疫性疾病遗传易感性的几个因素之一。

The aim of this study was to evaluate utilization of serum DNase I as a novel diagnostic biomarker of transient myocardial ischemia ;(1) A high diagnostic efficacy of serum DNase I activity levels could be observed in the early phase, even in unstable pectoris or non-ST segment elevation myocardial infarction patients who did not show elevation of conventional cardiac biomarkers. Thus, serum DNase I activity can be a useful biomarkers for the early diagnosis of these diseases inducing a transient myocardial ischemia after the onset of chest pain.(2) A transient elevation of the serum DNase I activity induced by a myocardial ischemia could in partial result from hypoxia-response of DNase I gene.(3) In non-synonymous SNPs of DNase I and I-like 3 genes, specific alleles producing an inactive/low activity-harboring enzyme were found. These alleles might be one of several factors involved in genetic predisposition to autoimmune diseases.